Special Issue "Vitamin C in Human Health and Disease"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 30 June 2020.

Special Issue Editor

Prof. Dr. Dariusz Nowak
Guest Editor
Department of Clinical Physiology, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland
Interests: antioxidant vitamins; plant polyphenols; exercise physiology; markers of oxidative stress; whole blood and neutrophils chemiluminescence; lung cancer; exhaled breath condensate; noninvasive markers of oxidative stress and pulmonary malignancy; dietary interventions to enhance the antioxidant activity of plasma

Special Issue Information

Dear Colleagues

Tens of thousands papers about vitamin C have been published since its discovery in 1912. Moreover, it was the first vitamin to be chemically produced and used for food fortification, as a food additive and the most common supplement. However, many questions related to the dietary intake of vitamin C and the risk of various types of cancer, prevention of cardiovascular disease, viral infections and dementia, effects on exercise performance, immune system, gene expression and cellular function still remain to be answered. Although there is a lack of sure evidence of the benefits of high intravenous doses of vitamin C in patients with late-stage cancer, thousands of them receive this treatment. Vitamin C is recognized as powerful water-soluble antioxidant. However, by reducing redox-active transition metal ions this vitamin can enhance the generation of hydroxyl and alkoxyl radicals. Whether these reactions can occur in vivo and may have physiological and clinical significance is unclear. The storage of fruits and vegetables reduces their content of vitamin C. Similarly, food processing (cooking, pasteurization, drying) decreases initial levels of this vitamin. Therefore, the optimization of these processes and the definition of their critical control points would be helpful for the prevention of vitamin C losses.

Submissions of original papers, reviews, meta-analyses, and commentaries on the afore-mentioned issues, and on other aspects of vitamin C absorption, metabolism, and elimination in the human body are welcome.

Prof. Dariusz Nowak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • vitamin C
  • supplementation
  • cancer
  • immune system
  • anti-oxidant activity
  • pro-oxidant activity
  • exercise performance
  • viral infections
  • fruit and vegetable storage
  • food processing
  • high doses of vitamin C
  • absorption and elimination of vitamin C
  • cardiovascular disease
  • dementia
  • cellular functions

Published Papers (1 paper)

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Open AccessReview
Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
Nutrients 2020, 12(5), 1501; https://doi.org/10.3390/nu12051501 - 21 May 2020
Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results [...] Read more.
Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular effects. Vitamin C, which belongs to antioxidants scavenging free radicals, also has a ‘second face’—as a pro-oxidative factor. However, whether is the latter nature a defect harmful to the cell, or whether a virtue that is a source of benefit? In this review, we discuss the effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS). Finally, we discuss the effect of vitamin C supplementation on biomarkers of oxidative DNA damage and review the evidence that vitamin C has radioprotective properties. Full article
(This article belongs to the Special Issue Vitamin C in Human Health and Disease)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Author: Piotr Potemski;Sylwia Debska-Szmich

Affiliation: Medical University of Lodz

Title: Vitamin C and the risk of cancer

Author: Boleslaw Karwowski

Affiliation: Medical University of Lodz

Title: The double sword of Vitamine C – DNA damage and protection.

Author:Konrad Walczak

Affiliation: Medical University of Lodz

Title: Is it possible that scurvy exists in the medicine of the 21st century? - based on a clinical case




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