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Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract

1
Department of Physiology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1142, New Zealand
2
Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3142; https://doi.org/10.3390/nu12103142
Received: 21 September 2020 / Revised: 6 October 2020 / Accepted: 9 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue Vitamin C in Human Health and Disease)
Cataracts or clouding of the lens is the leading cause of blindness in the world. Age and diabetes are major risk factors, and with an increasing aging and diabetic population, the burden of cataracts will grow. Cataract surgery is an effective way to restore vision; however, alternatives to cataract surgery are required to reduce the looming cataract epidemic. Since it is well established that oxidative damage plays a major role in the etiology of cataracts, antioxidants have been promoted as therapies to delay and/or prevent cataracts. However, many antioxidant interventions including vitamin C have produced mixed results as anti-cataract therapies. Progress has been made towards our understanding of lens physiology and the mechanisms involved in the delivery and uptake of antioxidants to the lens which may guide future studies aimed at addressing some of the inconsistencies seen in previous animal and human studies. Of interest is the potential for vitamin C based supplements in delaying the onset of cataracts post vitrectomy which occurs in up to 80% of patients within two years. These targeted approaches are required to reduce the burden of cataract on hospitals and improve the quality of life of our aging and diabetic population. View Full-Text
Keywords: vitamin C; lens; cataract; oxidative stress; vitreous humor; vitrectomy vitamin C; lens; cataract; oxidative stress; vitreous humor; vitrectomy
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MDPI and ACS Style

Lim, J.C.; Caballero Arredondo, M.; Braakhuis, A.J.; Donaldson, P.J. Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract. Nutrients 2020, 12, 3142. https://doi.org/10.3390/nu12103142

AMA Style

Lim JC, Caballero Arredondo M, Braakhuis AJ, Donaldson PJ. Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract. Nutrients. 2020; 12(10):3142. https://doi.org/10.3390/nu12103142

Chicago/Turabian Style

Lim, Julie C., Mariana Caballero Arredondo, Andrea J. Braakhuis, and Paul J. Donaldson 2020. "Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract" Nutrients 12, no. 10: 3142. https://doi.org/10.3390/nu12103142

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