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Impact of Nutritional Approaches on Inflammatory Bowel Disease Patients
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Impact of Nutritional Approaches on Inflammatory Bowel Disease Patients

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 7853

Special Issue Editors

Dr. Konstantinos Papadimitriou

E-Mail Website
Guest Editor
Faculty of Health and Rehabilitation Sciences, Metropolitan College of Thessaloniki, University of East London, 54624 Thessaloniki, Greece
Interests: ergogenic supplements; inflammatory bowel disease; swimming coaching; alternative motor skills learning approaches
Special Issues, Collections and Topics in MDPI journals
Dr. Sousana Papadopoulou

E-Mail Website
Guest Editor
Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, 57001 Thessaloniki, Greece
Interests: nutrition; anthropometry; physical activity; diet
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the Special Issue “Impact of Nutritional Approaches on Inflammatory Bowel Disease Patients”, which aims to investigate the effects of various nutrition patterns on IBD symptoms.

The primary objective of this Special Issue is to explore how different nutritional strategies can contribute to the prevention, remission, treatment, and even exacerbation of IBD among patients. Notably, many patients currently adopt a range of nutrition plans without a comprehensive understanding of the potential impact on their condition. Consequently, there is a discernible exacerbation of disease symptoms, significantly affecting these individuals' overall quality of life.

We invite researchers and experts in the field to contribute their significant insights to this crucial scientific topic. Studies such as nutritional interventions and recordings that aim to reduce the manifestation of inflammation and symptoms will offer much-needed guidance and support to health experts and patients striving to manage their conditions effectively in an area that needs more in-depth knowledge. 

Please consider submitting your original research articles, reviews, and clinical studies (case reports) to further our collective understanding of this important topic. Together, we can enhance patient care and improve outcomes for individuals living with IBD.

We look forward to receiving your contributions.

Dr. Konstantinos Papadimitriou
Dr. Sousana Papadopoulou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Crohn’s disease
  • ulcerative colitis
  • irritative colitis
  • inflammation
  • remission
  • exacerbation
  • macronutrients
  • micronutrients
  • treatment

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Published Papers (2 papers)

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Research

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12 pages, 1080 KB  
Article
Prevalence and Impact of Zinc Deficiency on Clinical Outcomes in Inflammatory Bowel Disease
by Hend Almuhaya, Raghad Alsalamah, Asma Sallam, Amgad Alonazy, Atheer AlAwwad, Gamal Mohamed, Abdulelah Almutairdi, Mashary Attamimi and Badr Al-Bawardy
Nutrients 2025, 17(21), 3378; https://doi.org/10.3390/nu17213378 - 28 Oct 2025
Abstract
Background: Inflammatory bowel disease (IBD) can lead to zinc deficiency, which plays a critical role in immune function and tissue repair. This study aims to determine the prevalence, clinical characteristics, and impact of zinc deficiency in IBD patients. Methods: This is a retrospective [...] Read more.
Background: Inflammatory bowel disease (IBD) can lead to zinc deficiency, which plays a critical role in immune function and tissue repair. This study aims to determine the prevalence, clinical characteristics, and impact of zinc deficiency in IBD patients. Methods: This is a retrospective study of patients aged ≥14 years with confirmed IBD and available zinc level measurement. Zinc deficiency was defined as a level <10.6 µmol/L. Primary outcomes included the prevalence of zinc deficiency and the characterization of the clinical profile of patients with zinc deficiency. Secondary outcomes included IBD-related hospitalizations, emergency room visits, surgeries, and complications (anemia, small bowel obstruction, new perianal disease, intra-abdominal abscess). Results: Among 447 patients (54.4% male; 79.2% Crohn’s disease) with a median age of 29 years (IQR: 22–38), 45.6% had zinc deficiency (83.8% Crohn’s disease). Zinc-deficient patients had higher C-reactive protein and fecal calprotectin (both p < 0.001) levels, and were more likely to be on corticosteroids (p = 0.04). Zinc deficiency was associated with higher rates of IBD-related hospitalizations (48.0% vs. 17.7%), surgeries (19.6% vs. 5.8%), complications (30.4% vs. 12.4%), and emergency room visits (40.2% vs. 17.3%) (all p < 0.001). Upon multivariate analysis, predictors of IBD-related hospitalization were zinc deficiency (OR 2.42, 95% CI 1.07–5.48, p = 0.03) and low albumin (OR 9.03, 95% CI 3.38–24.15, p < 0.001). Zinc deficiency was associated with IBD-related surgeries (OR 5.23, 95% CI 1.27–21.45, p = 0.02) and complications (OR 3.98, 95% CI 1.52–10.41, p = 0.005). Conclusions: Zinc deficiency is prevalent in patients with IBD, associated with a high inflammatory burden, and was linked to worse clinical outcomes after controlling for markers of inflammation. Full article
(This article belongs to the Special Issue Impact of Nutritional Approaches on Inflammatory Bowel Disease Patients)
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Review

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39 pages, 852 KB  
Review
Dietary Interventions and Oral Nutritional Supplementation in Inflammatory Bowel Disease: Current Evidence and Future Directions
by Brigida Barberio, Luisa Bertin, Sonia Facchin, Erica Bonazzi, Sara Cusano, Giulia Romanelli, Francesco Francini Pesenti, Emanuela Cazzaniga, Paola Palestini, Fabiana Zingone and Edoardo Vincenzo Savarino
Nutrients 2025, 17(11), 1879; https://doi.org/10.3390/nu17111879 - 30 May 2025
Cited by 4 | Viewed by 6752
Abstract
Background: Nutritional management has become an integral part of Inflammatory Bowel Disease (IBD) care, with growing evidence supporting specific dietary interventions alongside pharmacologic therapy. However, clinical guidance remains fragmented due to heterogeneous study designs and variable endpoints. Objectives: This review critically examines the [...] Read more.
Background: Nutritional management has become an integral part of Inflammatory Bowel Disease (IBD) care, with growing evidence supporting specific dietary interventions alongside pharmacologic therapy. However, clinical guidance remains fragmented due to heterogeneous study designs and variable endpoints. Objectives: This review critically examines the current evidence on dietary strategies and oral nutritional supplementation (ONS) in both Crohn’s Disease (CD) and Ulcerative Colitis (UC), highlighting their clinical applications, mechanisms of action, and limitations. Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases, analyzing studies on various dietary approaches and ONS in IBD. Results: Exclusive Enteral Nutrition (EEN) is a first-line therapy in pediatric CD, while partial enteral nutrition (PEN) and the Crohn’s Disease Exclusion Diet (CDED) show promising efficacy and better adherence in both children and adults. Whole-food-based interventions, including the Mediterranean Diet, Specific Carbohydrate Diet, plant-based diets, and emerging strategies such as CD-TREAT and the Tasty & Healthy diet, have demonstrated varying levels of benefit in disease maintenance and symptom control. Targeted exclusion diets—such as low-FODMAP, low-emulsifier, and low-sulfur diets—may relieve functional symptoms and influence inflammatory activity, although evidence remains preliminary. ONS plays a pivotal role in addressing malnutrition and improving outcomes in perioperative and hospitalized patients. Conclusions: Dietary interventions and ONS represent valuable therapeutic tools in IBD management. Future research should prioritize standardized, well-powered clinical trials and personalized nutritional approaches to better define their role within integrated care pathways. Full article
(This article belongs to the Special Issue Impact of Nutritional Approaches on Inflammatory Bowel Disease Patients)
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