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The Role of Nutrition in Osteoarthritis Development

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 25 November 2024 | Viewed by 4760

Special Issue Editor


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Guest Editor
Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia 2404, Cyprus
Interests: osteoarthritis; cartilage damage; skeletal remodelling; bone metabolism; microbiome; probiotics; prebiotics

Special Issue Information

Dear Colleagues,

Managing osteoarthritis (OA) has become a worldwide challenge. OA is thought to have a multifactorial aetiology, and therefore the underlying cause is incompletely understood. Factors such as mechanical loading, inflammation, metabolic alterations and joint injury play a major role in the pathogenesis of OA. Current medical management is primarily based on trying to control pain, whereas non-pharmacological practices focus on weight loss and physical activity.

Recently, there has been an increasing interest in the potential benefits of diet and nutrition on the prevention and management of OA. Evidence thus far supports the hypothesis that dietary components with anti-inflammatory and antioxidant properties, such as polyunsaturated fatty acids and vitamins C and E, may benefit OA. However, clinically meaningful long-term effects of different nutrients on OA remain to be determined. Any new research on these topics should cast new light on nutrition and its relationship with OA pathogenesis, and have the potential to pave the way for new forms of therapy based on dietary manipulation.

This Special Issue of Nutrients entitled “The Role of Nutrition in Osteoarthritis Development” welcomes original clinical and pre-clinical research studies as well as review articles examining the impact of nutrition on OA. Systematic review and meta-analysis contributions summarizing the current evidence on nutrition and OA interaction are also welcome in this effort.

Dr. Antonia Sophocleous
Guest Editor

Manuscript Submission Information

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Keywords

  • osteoarthritis
  • obesity-associated osteoarthritis
  • inflammation
  • nutrition
  • micronutrients
  • antioxidants
  • polyunsaturated fatty acids
  • vitamins
  • gut microbiome

Published Papers (3 papers)

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Editorial

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4 pages, 230 KiB  
Editorial
The Role of Nutrition in Osteoarthritis Development
by Antonia Sophocleous
Nutrients 2023, 15(20), 4336; https://doi.org/10.3390/nu15204336 - 12 Oct 2023
Cited by 2 | Viewed by 2397
Abstract
Osteoarthritis (OA) prevalence has increased 113% since 1990, and currently more than half a billion people worldwide are living with this slowly progressing, degenerative joint disease [...] Full article
(This article belongs to the Special Issue The Role of Nutrition in Osteoarthritis Development)

Research

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14 pages, 2051 KiB  
Article
S-Equol Ameliorates Menopausal Osteoarthritis in Rats through Reducing Oxidative Stress and Cartilage Degradation
by Yu-Chen Hu, Tzu-Ching Huang, Li-Wen Huang, Hsiao-Ling Cheng, Bau-Shan Hsieh and Kee-Lung Chang
Nutrients 2024, 16(14), 2364; https://doi.org/10.3390/nu16142364 - 21 Jul 2024
Viewed by 445
Abstract
Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage destruction. Menopausal and postmenopausal women are susceptible to both OA and osteoporosis. S-equol, a soy isoflavone-derived molecule, is known to reduce osteoporosis in estrogen-deficient mice, but its role in OA remains unknown. [...] Read more.
Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage destruction. Menopausal and postmenopausal women are susceptible to both OA and osteoporosis. S-equol, a soy isoflavone-derived molecule, is known to reduce osteoporosis in estrogen-deficient mice, but its role in OA remains unknown. This study aimed to explore the effect of S-equol on different degrees of menopausal OA in female Sprague–Dawley (SD) rats induced by estrogen deficiency caused by bilateral ovariectomy (OVX) combined with intra-articular injection of mono-iodoacetate (MIA). Knee joint histopathological change; serum biomarkers of bone turnover, including N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (CTX-I) and N-terminal telopeptide of type I collagen (NTX-I); the cartilage degradation biomarkers hyaluronic acid (HA) and N-terminal propeptide of type II procollagen (PIINP); and the matrix-degrading enzymes matrix metalloproteinases (MMP)-1, MMP-3 and MMP-13, as well as the oxidative stress-inducing molecules nitric oxide (NO) and hydrogen peroxide (H2O2), were assessed for evaluation of OA progression after S-equol supplementation for 8 weeks. The results showed that OVX without or with MIA injection induced various severity levels of menopausal OA by increasing pathological damage, oxidative stress, and cartilage matrix degradation to various degrees. Moreover, S-equol supplementation could significantly reduce these increased biomarkers in different severity levels of OA. This indicates that S-equol can lessen menopausal OA progression by reducing oxidative stress and the matrix-degrading enzymes involved in cartilage degradation. Full article
(This article belongs to the Special Issue The Role of Nutrition in Osteoarthritis Development)
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Other

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13 pages, 1379 KiB  
Systematic Review
The Effect of Probiotics on the Management of Pain and Inflammation in Osteoarthritis: A Systematic Review and Meta-Analysis of Clinical Studies
by Maria Moyseos, Jenny Michael, Nuno Ferreira and Antonia Sophocleous
Nutrients 2024, 16(14), 2243; https://doi.org/10.3390/nu16142243 - 12 Jul 2024
Viewed by 987
Abstract
Osteoarthritis (OA) is one of the most common musculoskeletal disorders. Recently, research has focused on the role of intestinal microbiome dysbiosis in OA. The aim of this study was to systematically review randomized intervention clinical studies investigating the effect of probiotics on the [...] Read more.
Osteoarthritis (OA) is one of the most common musculoskeletal disorders. Recently, research has focused on the role of intestinal microbiome dysbiosis in OA. The aim of this study was to systematically review randomized intervention clinical studies investigating the effect of probiotics on the management of OA-related pain and inflammation. Pre-clinical studies and non-randomized trials were excluded. A literature search was conducted using MEDLINE, EMBASE, and Web of Science. Study quality was assessed with the Cochrane risk of bias (RoB2) tool and the Risk of Bias in N-of-1 Trials (RoBiNT) scale. RevMan was used for the meta-analysis. Outcome measures assessed self-reported pain, stiffness and impediment, and serum hs-CRP. Three studies, with 501 participants, were considered eligible for qualitative synthesis and meta-analysis. A significant reduction in symptoms across all outcomes measured, except stiffness, was evident with Lactobacillus casei Shirota. However, all other probiotics reviewed did not seem to have any effect on the measured outcomes. Pre-clinical evidence, along with the RCTs reviewed, suggests that probiotics of the Lactobacillus strains might be of use for managing pain and inflammation in OA. Considering the small number of studies included in the present review and the possible risk of bias, we conclude that further studies on the role of probiotics in humans with OA are warranted. Full article
(This article belongs to the Special Issue The Role of Nutrition in Osteoarthritis Development)
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