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Bone-Health-Promoting Bioactive Nutrition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 5 November 2025 | Viewed by 272

Special Issue Editor


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Guest Editor
Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia 2404, Cyprus
Interests: osteoarthritis; cartilage damage; skeletal remodelling; bone metabolism; microbiome; probiotics; prebiotics
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Special Issue Information

Dear Colleagues,

Foods that offer health benefits beyond basic nutrition, known as bioactive or functional foods, have been thoroughly studied since the beginning of the 20th century. Minerals, vitamins, antioxidants and phytochemicals boost health, support the immune system and reduce inflammation.

The musculoskeletal system, essential for body support, movement, internal organ protection, blood cell production and mineral storage, could not have remained unaffected by bioactive foods. In recent years, research has increasingly highlighted the potential benefits of functional nutrition in promoting musculoskeletal wellness. Evidence thus far supports the notion that plant- and animal-derived bioactive compounds are promising candidates for improving bone health. However, clinically meaningful long-term effects and the safety of functional compounds in terms of skeletal vitality remain to be determined. Any new research in these areas could shed light on novel functional food ingredients and their role in enhancing bone wellness.

This Special Issue of Nutrients, entitled “Bone-Health-Promoting Bioactive Nutrition”, welcomes original pre-clinical and clinical research studies and review articles examining the impact of functional foods and food-based bioactive compounds on bone health. Systematic reviews and meta-analyses summarizing the current evidence on the interplay between health-enhancing nutrition and skeletal wellness are also welcome.

Dr. Antonia Sophocleous
Guest Editor

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone health
  • musculoskeletal system
  • osteoarthritis
  • osteoporosis
  • skeletal remodelling
  • bone metabolism
  • probiotics
  • functional food
  • bioactive nutrition
  • minerals
  • vitamins
  • antioxidants
  • phytochemicals
  • nutraceuticals
  • nutritionally active food

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Published Papers (1 paper)

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Review

16 pages, 1049 KiB  
Review
Influence of Wine on Bone Mineral Density
by Nathália Dantas Duarte, Paula Buzo Frigério, Felipe de Souza Duarte, Roberta Okamoto, Daniela Vieira Buchaim, Geraldo Marco Rosa Junior, Cleuber Rodrigo de Souza Bueno, Carlos Henrique Bertoni Reis, Rogerio Leone Buchaim and João Paulo Mardegan Issa
Nutrients 2025, 17(12), 1981; https://doi.org/10.3390/nu17121981 - 11 Jun 2025
Abstract
Background: Considering the increasing interest in strategies to prevent osteoporosis and other bone-related conditions, it is relevant to critically assess the existing evidence on the potential benefits of phenolic compounds in wine on bone metabolism. Objectives: This integrative review aims to [...] Read more.
Background: Considering the increasing interest in strategies to prevent osteoporosis and other bone-related conditions, it is relevant to critically assess the existing evidence on the potential benefits of phenolic compounds in wine on bone metabolism. Objectives: This integrative review aims to evaluate clinical and animal studies investigating the influence of wine consumption on bone mineral density (BMD). Methods: The search was conducted in PubMed, Scopus, and Embase databases until April 2025. The key question was: “Does wine consumption influence BMD?”. Results: After searching the identified databases, 108 studies were screened, and 7 were included in the final analysis. Conclusions: This review suggests a possible association between light to moderate wine consumption and favorable effects on BMD, particularly in the spine and femoral neck. However, these findings should be interpreted cautiously due to the predominance of observational studies. Future RCTs and systematic reviews must clarify wine’s potential role in bone health and explore non-alcoholic or low-alcohol wine alternatives with similar polyphenol content. Full article
(This article belongs to the Special Issue Bone-Health-Promoting Bioactive Nutrition)
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