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Dietary Supplements for Human Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 15 November 2025 | Viewed by 1477

Special Issue Editors


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Guest Editor
Dipartimento di Farmacia, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
Interests: phytochemistry; natural products; coumarin; chemical synthesis; HPLC; oxyprenylated; plant secondary metabolites identification and quantification; anti-inflammatory and anticancer activity
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Guest Editor
Department of Pharmacy, ‘G. d’Annunzio’ Chieti-Pescara University, Via dei Vestini 31, 66100 Chieti, Italy
Interests: pharmaceutical analysis; chemical synthesis; medicinal chemistry; phytochemistry; plant natural compounds; plant extraction; HPLC; GC/MS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are setting up a Special Issue with the aim of providing updated information on how dietary supplements may represent an integrative approach to regulate several disorders ranging from chronic pain, inflammatory diseases, to metabolic disorders.

Chronic inflammation and metabolic disorders strongly contribute to the onset of several pathological diseases. They are characterized by complex and multifaceted conditions which can vary in location, precipitating factors, and severity, and can be related to neurologic, urologic, GI, gynecologic, and musculoskeletal-related disorders.

There is growing evidence that air pollution, drug abuse, and unhealthy lifestyles affect quality-of-life and are also related to influencing factors that promote health disorders. This can lead a significant proportion of the population to have a decline in their well-being over an extended period. In this context, dietary supplement intake represents an essential factor in human behavior which can support overall health and well-being, and is an effective strategy in the regulation and reduction in pathological conditions.

A wide range of nutrients, new natural molecular entities, and active ingredients are present in food supplements, including various food plants and herbal extracts. In the field of food science, the interaction of food choices and the effect of cumulative exposure to different dietary components may guide new strategies for personalized prevention of the onset and progression of chronic diseases.

New findings on the role played by functional food and related ingredients in human physiology and pathology, as well as their uses in potential therapeutic applications, are needed and represent a field of growing interest.

In this Special Issue of Nutrients, we welcome original research articles (including animal and clinical studies) and review articles on the current state of research in this field.

Dr. Salvatore Genovese
Dr. Serena Fiorito
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary supplements
  • natural molecular entities
  • active ingredients
  • food plants
  • herbal extracts
  • pathological conditions
  • prevention
  • therapeutic applications

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Published Papers (1 paper)

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Research

14 pages, 1319 KiB  
Article
Effect of Hydroponically Grown Red Panax Ginseng on Perceived Stress Level, Emotional Processing, and Cognitive Functions in Moderately Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study
by Valérie Dormal, Lucas Jonniaux, Marine Buchet, Laurent Simar, Sylvie Copine and Louise Deldicque
Nutrients 2025, 17(6), 955; https://doi.org/10.3390/nu17060955 - 9 Mar 2025
Viewed by 1195
Abstract
Background/objectives: Chronic stress is a pervasive issue affecting individuals worldwide, with profound implications for mental and physical well-being. Panax ginseng, a widely used herbal supplement renowned for its adaptogenic properties, is hypothesized to alleviate some stress effects. This study aims to evaluate the [...] Read more.
Background/objectives: Chronic stress is a pervasive issue affecting individuals worldwide, with profound implications for mental and physical well-being. Panax ginseng, a widely used herbal supplement renowned for its adaptogenic properties, is hypothesized to alleviate some stress effects. This study aims to evaluate the impact of hydroponically grown Red Panax ginseng root powder with a high level of rare ginsenosides supplementation on perceived stress levels, as well as on the emotional and cognitive abilities of moderately stressed participants. Methods: A randomized, double-blind, controlled study was conducted with 149 participants. They were randomly assigned to either the Ginseng supplementation group (N = 72; 200 mg/day, including 24 mg of ginsenosides) or the Placebo group (N = 77). The intervention lasted for 3 weeks. The perceived stress level was measured at baseline (D0) and at the end of the intervention (D21) using a validated scale (PSS) alongside assessments of emotional (BDI and PANAS) and cognitive abilities (CANTAB subtests). Results: Significantly larger decreases in the PSS and negative affect score (PANAS) were observed following intervention in the Ginseng group compared with the Placebo group. Compared to the Placebo group, participants in the Ginseng group showed faster response latencies during a spatial planning task (OTSC subtest). In addition, there was a marginally larger decrease in the BDI score in the Ginseng group. Conclusions: These results confirm the emotional and cognitive benefits of Red Panax ginseng in moderately stressed adults and pave the way for further exploration of its use as a promising approach to improving psychological well-being. Full article
(This article belongs to the Special Issue Dietary Supplements for Human Health and Disease)
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