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Nutrients
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The Adverse Effects of Trans Fatty Acids in the Diet...
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The Adverse Effects of Trans Fatty Acids in the Diet on Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: closed (15 May 2026) | Viewed by 1275

Editor

Prof. Dr. Hanna Mojska

E-Mail Website
Guest Editor
Department of Nutrition and Nutritive Value of Food, National Institute of Public Health, NIH—National Research Institute, 24 Chocimska Street, 00-791 Warsaw, Poland
Interests: acrylamide; fatty acids; TFAs; DHA; food; human milk; biomarkers; exposure estimation; risk assessment; diet-related disease

Special Issue Information

Dear Colleagues,

It is now widely known that excessive consumption of trans unsaturated fatty acids (TFAs) leads to increased levels of total cholesterol and LDL-cholesterol in blood serum, as well as decreased levels of HDL-cholesterol, which contributes to the development of cardiovascular and cardiometabolic diseases. Moreover, the inverse correlation observed between the concentration of TFAs and long-chain polyunsaturated fatty acids (LC-PUFAs) in maternal serum, cord blood, and breast milk may indicate a risk of disorders in the normal development of the fetus and breastfed infants. The presence of TFAs in food comes from both natural sources (r-TFAs from ruminant milk and meat) and industrial sources (i-TFAs from partially hydrogenated vegetable and fish oils/fats). Many countries have introduced mandatory restrictions on the use of i-TFAs and/or the obligation to indicate the presence of TFAs on food labels. Despite this, TFAs are still present in food and diet, posing a risk to human health. The aim of this Special Issue is to present current findings on the relationship between dietary TFA intake and the risk of developing diseases and health disorders. We invite the submission of published data on TFAs content in food, diet, and body fluids, as well as assessments of human exposure to TFAs.

Prof. Dr. Hanna Mojska
Guest Editor

Manuscript Submission Information

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Keywords

  • trans fatty acids (TFAs)
  • r-TFAs
  • i-TFAs
  • diet-related diseases
  • food
  • body fluids
  • analytical methods
  • estimation of exposure
  • nutritional recommendations

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Published Papers (1 paper)

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Research

32 pages, 3174 KB  
Article
Trans Fatty Acids Content in Breast Milk as a Marker of Their Short-Term Intake Within the Breastfeeding Mother’s Diet: A Single-Participant Pilot Study
by Edyta Jasińska-Melon, Hanna Mojska and Agnieszka Bzikowska-Jura
Nutrients 2026, 18(13), 2177; https://doi.org/10.3390/nu18132177 - 4 Jul 2026
Viewed by 517
Abstract
Introduction: Breast milk is the best food for a growing infant during the first 6 months of life. The presence of trans fatty acids (TFAs) in breast milk can interfere with the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), increasing the risk of [...] Read more.
Introduction: Breast milk is the best food for a growing infant during the first 6 months of life. The presence of trans fatty acids (TFAs) in breast milk can interfere with the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), increasing the risk of developing, among other issues, asthma or atopic dermatitis. TFAs are not synthesised de novo in the human body. Their content in breast milk may be a good marker of short-term dietary intake of these compounds by breastfeeding mothers. However, the literature shows differences in the assessment of the relationship between dietary TFAs intake and TFAs content in breast milk. Furthermore, the decrease in the TFAs content in food observed recently seems to make it impossible to use Craig-Schmidt’s formula to estimate the TFAs content in the diet or in breast milk. The aim of this study was to confirm the possibility of using TFAs content in breast milk as a marker of their short-term intake within the breastfeeding mother’s diet, together with an attempt at preliminary quantitative determination of the relationship between these parameters. Materials: The study material was collected from a single breastfeeding mother and included 10 breast milk samples and 10 samples of daily food rations reconstructed based on the 24 h food consumption survey. Methods: The content of fatty acids, including TFAs, was determined by gas chromatography–mass spectrometry (GC-MS). Results: The TFAs content in the whole-day mother’s diet and in 100 mL of breast milk ranged from 0.11 to 0.54 g/day and from 0.02 to 0.07 g, respectively. A strong statistically significant (p < 0.05) positive correlation between these parameters was found. Equations for an exploratory linear relationship between the TFAs content in a breastfeeding mother’s diet and the concentration of these fatty acids in breast milk have been developed. Due to the small number of samples, these data should be interpreted very cautiously and validated in a larger cohort. Conclusions: This single-participant pilot study suggests that TFAs content in breast milk may be a marker of the dietary intake of these compounds from the previous day. It seems that the dietary habits of breastfeeding mothers of twins are a significant factor influencing the composition of breast milk and, consequently, the nutritional quality of breastfed infants. Full article
(This article belongs to the Special Issue The Adverse Effects of Trans Fatty Acids in the Diet on Human Health)
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