Biochemical Mechanisms of Natural Compounds in Chronic Diseases

Dear Colleagues,

Chronic diseases, including cardiovascular disorders, diabetes, neurodegenerative conditions, and cancer, represent major global health challenges. Natural compounds derived from plants, fungi, and marine organisms have shown promising therapeutic potential due to their biochemical properties. These compounds modulate key cellular pathways, such as oxidative stress, inflammation, and apoptosis, through interactions with molecular targets such as transcription factors (e.g., NF-κB, Nrf2), enzymes, and signaling proteins. Polyphenols, alkaloids, flavonoids, and terpenoids exhibit antioxidant, anti-inflammatory, and immunomodulatory effects, limiting disease progression. A greater understanding of the biochemical mechanisms underlying these natural compounds could facilitate their integration into preventive and therapeutic strategies.

For this Special Issue, we welcome all narrative and systematic reviews and original research articles on exploring the biochemical mechanisms of extracted natural compounds in chronic diseases.

Dr. Paola Stiuso
Dr. Stefania Lama
Guest Editors

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