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Nutrients
Special Issues
Lifestyle Interventions for Diabetes in Physical Activity and Beyond
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Lifestyle Interventions for Diabetes in Physical Activity and Beyond

A Special Issue of Nutrients (ISSN 2072-6643) belonging to the section "Nutrition and Diabetes".

Deadline for manuscript submissions: 5 March 2027 | Viewed by 1465

Editors

Dr. Josep Julve

E-Mail Website
Guest Editor
1. Research Group in Endocrinology, Diabetes and Nutrition, Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain
2. Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
Interests: diabetes; obesity; MASLD; cardiomyopathy; atherosclerosis; lipid and lipoprotein metabolism; metabolomics; gut microbiota; animal models
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Didac Mauricio

E-Mail Website
Guest Editor
1. Department of Endocrinology and Nutrition, Hospital de la Sant Creu i Sant Pau (IR SANT PAU), 08041 Barcelona, Spain
2. Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
3. Faculty of Medicine, University of Vic—Central University of Catalonia, Vic, Spain
Interests: diabetes; MASLD; atherosclerosis; lipoprotein metabolism; biomarkers; clinical trials; human cohort studies
Special Issues, Collections and Topics in MDPI journals
Dr. Marina Idalia Rojo-López

E-Mail Website
Guest Editor Assistant
Department of Endocrinology, Diabetes & Nutrition, Institut de Recerca Sant Pau (IR Sant Pau), Sant Quintí 77-79, 08041 Barcelona, Spain
Interests: diabetes complications; MASLD; atherosclerosis; microbiota; metabolomics; nutrition; diet

Special Issue Information

Dear Colleagues,

Lifestyle interventions are essential for preventing and managing type 2 diabetes and related metabolic diseases. Evidence highlights the value of multidimensional strategies integrating physical activity, targeted dietary modifications, weight management, and behavioral support to strengthen long-term adherence. Personalized programs that incorporate therapeutic education and digital health tools for behavior tracking and metabolic monitoring have shown strong effectiveness. Additionally, endocrine regulation, sleep optimization, stress management, and psychosocial support are increasingly recognized as key modulators of metabolic risk in individuals with diabetes. Together, these holistic strategies improve metabolic outcomes, reduce complications, and enhance quality of life.

Beyond glycemic control, lifestyle interventions also benefit cardiovascular health and frequent diabetes-related conditions, such as metabolic dysfunction-associated steatotic liver disease (MASLD), neuropathy, retinopathy, and nephropathy. Emerging evidence underscores the role of the gut microbiota as a mediator of nutritional and lifestyle adaptations, influencing systemic metabolism, inflammation, and organ-specific outcomes.

For this Special Issue, we seek high-quality contributions examining the effects of lifestyle interventions on diabetes prevention and management, with a focus on cardiometabolic health, MASLD, microvascular complications, and microbiota-mediated mechanisms. Original research, systematic reviews, and meta-analyses exploring mechanistic, clinical, and implementation aspects of physical activity, nutrition, behavioral strategies, and digital health solutions are encouraged to advance evidence-based practice.

Dr. Josep Julve
Prof. Dr. Didac Mauricio
Guest Editors

Dr. Marina Idalia Rojo-López
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • physical activity
  • nutrition
  • weight loss
  • sleep optimization
  • stress management
  • psychosocial support
  • microbiota
  • fasting
  • dietary patterns
  • dietary intervention
  • dietary biomarkers

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Published Papers (2 papers)

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Research

19 pages, 1594 KB  
Article
Effects of a Multicomponent Lifestyle Intervention on Behavioral and Cardiometabolic Outcomes in Adults with Type 2 Diabetes Mellitus in the Peruvian Amazon
by Mónica Yenji Chia Sánchez, Alexander Javier Iman Torres, Wilson Guerra Sangama, Carlos Antonio Li Loo Kung, Susy Karina Dávila Panduro, Oscar Huaman Gutierrez, Antonio Castillo-Paredes and Jose Jairo Narrea Vargas
Nutrients 2026, 18(16), 2699; https://doi.org/10.3390/nu18162699 - 18 Aug 2026
Viewed by 346
Abstract
Introduction: Lifestyle interventions are a fundamental component of type 2 diabetes mellitus management; however, evidence from real-world clinical settings regarding multicomponent interventions that simultaneously evaluate behavioral, metabolic, and anthropometric outcomes remains limited. Objective: To evaluate the effect of a multicomponent lifestyle intervention program [...] Read more.
Introduction: Lifestyle interventions are a fundamental component of type 2 diabetes mellitus management; however, evidence from real-world clinical settings regarding multicomponent interventions that simultaneously evaluate behavioral, metabolic, and anthropometric outcomes remains limited. Objective: To evaluate the effect of a multicomponent lifestyle intervention program on dietary habits, biochemical parameters, physical activity, and anthropometric indicators in adults with type 2 diabetes mellitus in the Peruvian Amazon. Methods: A quasi-experimental study with a non-randomized control group and pre–post assessments was conducted among 144 adults with type 2 diabetes mellitus (72 in the intervention group and 72 in the control group) receiving care at a hospital in the Peruvian Amazon. The three-month intervention included nutrition education sessions, practical workshops, group-based physical activity sessions involving traditional dance and Zumba, home visits, and follow-up through telephone calls and WhatsApp. Dietary habits, fasting blood glucose (FBG), glycated hemoglobin (HbA1c), lipid profile, physical activity (PA), body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) were assessed. Intervention effects were estimated using linear mixed-effects regression models adjusted for age, sex, and disease duration. Results: Compared with the control group, participants receiving the intervention experienced greater improvements in dietary habits (β = 17.85; 95% CI: 16.80 to 18.89; p < 0.001), together with greater reductions in FBG (β = −84.23 mg/dL; 95% CI: −100.45 to −68.01; p < 0.001) and HbA1c (β = −2.32 percentage points; 95% CI: −2.74 to −1.90; p < 0.001). Greater reductions were also observed in triglycerides (β = −53.68 mg/dL), total cholesterol (β = −31.73 mg/dL), BMI (β = −1.67 kg/m2), WC (β = −5.31 cm), and WHtR (β = −0.034) (all p < file0.001). PA increased to a greater extent among participants receiving the intervention (β = 3015.40 MET-min/week; 95% CI: 2769.81 to 3260.99; p < 0.001), whereas no significant between-group difference in change was observed for serum creatinine (p = 0.075). Conclusions: Participation in a three-month multicomponent lifestyle intervention was associated with greater improvements in dietary habits, physical activity, glycemic control, lipid profile, and anthropometric indicators compared with usual care among adults with type 2 diabetes mellitus in the Peruvian Amazon. Full article
(This article belongs to the Special Issue Lifestyle Interventions for Diabetes in Physical Activity and Beyond)
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20 pages, 4290 KB  
Article
A Comparison of the Interstitial and Blood Glucose Responses Following Consumption of Different Carbohydrate-Containing Beverages in Humans: A Randomised Controlled Trial
by Ross Hamilton, Stephen C. Bain and Richard M. Bracken
Nutrients 2026, 18(12), 2033; https://doi.org/10.3390/nu18122033 - 22 Jun 2026
Viewed by 566
Abstract
Objectives: This study investigated the relationship between interstitial and blood glucose concentrations following ingestion of carbohydrate-containing drinks differing in carbohydrate amount, osmolarity, and glycaemic index. Methods: Ten healthy adults (nine male; age: 22 ± 1 y; height: 177 ± 12 cm; weight: 75 [...] Read more.
Objectives: This study investigated the relationship between interstitial and blood glucose concentrations following ingestion of carbohydrate-containing drinks differing in carbohydrate amount, osmolarity, and glycaemic index. Methods: Ten healthy adults (nine male; age: 22 ± 1 y; height: 177 ± 12 cm; weight: 75 ± 14 kg) completed a double-blind, randomised cross-over study with seven beverage trials varying in carbohydrate (CHO) characteristics. Blood samples were collected at rest and over two hours, while interstitial glucose ([iG]) was recorded using a continuous glucose monitor (Supersapiens, Atlanta, USA). Glycaemic metrics and mean absolute relative difference (MARD) were calculated for hypoglycaemic, euglycaemic, and hyperglycaemic ranges. Data were analysed using repeated-measures ANOVA with Bonferroni correction and paired t-tests (p ≤ 0.05). Results: Interstitial and blood glucose concentrations were similar at baseline but diverged post-ingestion. MARD varied by glucose rate and direction, exceeding 20% during rapid declines (>2 mg/dL/min), where [iG] underestimated [BG] by −7.3 ± 27.1 mg/dL. Accuracy was highest during stable glucose (MARD = 10.5 ± 8.6%). Carbohydrate amount and glycaemic index influenced peak glucose, whereas beverage concentration (5–20%) had minimal effect when CHO amount was fixed, though variation in CGM agreement appeared during post-peak declines. Conclusions: CGM tracked blood glucose overall but showed reduced accuracy during rapid falls or hypoglycaemia. Carbohydrate properties influenced glycaemic response but not sensor agreement when CHO load was constant. Glucose rate and direction of change are key considerations for interpreting CGM data in research and applied settings. Full article
(This article belongs to the Special Issue Lifestyle Interventions for Diabetes in Physical Activity and Beyond)
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