nutrients-logo

Journal Browser

Journal Browser

Magnesium in Aging, Health and Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 15 February 2026 | Viewed by 700

Special Issue Editors


E-Mail Website
Guest Editor
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90100 Palermo, Italy
Interests: aging; health; diseases; nutrition; magnesium
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Medicine, Kore University of Enna, 94100 Enna, Italy
Interests: aging; health; diseases; nutrition; magnesium

Special Issue Information

Dear Colleagues,

Magnesium (Mg) metabolism undergoes several changes with aging, including reduced dietary intake, impaired intestinal absorption, and increased renal excretion. Mild Mg deficiency is often asymptomatic, with vague or absent clinical signs, making it easily overlooked. However, chronic Mg deficiency promotes oxidative stress by increasing free radical production, contributing to the development of various age-related diseases.

Low Mg levels have been linked to a wide range of conditions, including cardiovascular diseases, hypertension, stroke, metabolic syndrome, type 2 diabetes, respiratory disorders such as asthma, depression, psychiatric conditions, Alzheimer’s disease, other dementias, chronic fatigue, fibromyalgia, bone fragility, and cancer.

Given its widespread physiological roles and potential impact on aging-related pathologies, Mg status deserves careful attention, particularly in older adults. Dietary Mg intake and/or supplementation—including Mg-rich water sources—should be considered in the prevention or correction of Mg deficits.

In this Special Issue, we welcome original research, reviews, and meta-analyses encompassing in vitro, animal, and human in vivo studies. Submissions addressing genetic, epigenetic, and metabolic aspects of Mg, as well as public health strategies for Mg fortification, are strongly encouraged. Our goal is to advance the understanding of how Mg may contribute to health optimization.

Prof. Dr. Mario Barbagallo
Prof. Dr. Ligia J. Domínguez
Prof. Dr. Nicola Veronese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnesium
  • health
  • nutrition
  • diabetes
  • hypertension

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

19 pages, 887 KB  
Review
Novel Scale for Clinical Identification of Adverse Magnesium/Calcium Imbalances: Applications and Perspectives
by Deanna J. Nelson, Andrea Rosanoff and Bodo von Ehrlich
Nutrients 2025, 17(23), 3662; https://doi.org/10.3390/nu17233662 - 23 Nov 2025
Cited by 1 | Viewed by 407
Abstract
Background/Objectives: Calcium (Ca) and magnesium (Mg) are mutual antagonists that interact in a majority of physiological processes. Thus, maintaining a balance between these two minerals is essential for functional homeostasis. Mg deficiency plays a role in the course and severity of a wide [...] Read more.
Background/Objectives: Calcium (Ca) and magnesium (Mg) are mutual antagonists that interact in a majority of physiological processes. Thus, maintaining a balance between these two minerals is essential for functional homeostasis. Mg deficiency plays a role in the course and severity of a wide range of chronic health conditions. This knowledge, however, has not translated into active incorporation of serum Mg determination as a reliable diagnostic tool for physiological Mg deficit. Methods: Pioneering work by von Ehrlich and Rosanoff has prompted development of a simple algorithm and scale for using serum Ca and Mg determinations to identify subclinical (i.e., “hidden”) physiological Mg deficiencies. This novel serum Mg/Ca–Ca/Mg scale uses determinations of total serum Ca and Mg and their ratios to alert clinicians to avoidable risks associated with chronic latent Mg deficiency. This review applies this scale to 10 published clinical studies reporting the serum (or plasma) ratio between Mg and Ca. Results: In all 10 studies, application of the serum Mg/Ca–Ca/Mg scale diagnosed deficit Mg status more reliably than serum Mg alone. Conclusions: This review provides both illustrations of the value of the novel scale and support for its consideration in clinical practice and Mg research. Full article
(This article belongs to the Special Issue Magnesium in Aging, Health and Diseases)
Show Figures

Figure 1

Back to TopTop