Frailty and Frequent Hospitalizations in Older Adults: Risk, Management, and Interventions

A special issue of Diseases (ISSN 2079-9721).

Deadline for manuscript submissions: 31 March 2026 | Viewed by 575

Special Issue Editors


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Guest Editor
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90127 Palermo, Italy
Interests: geriatrics; dementia; sarcopenia; neurodegenerative diseases; public health; aging; clinical nutrition; global health; vaccines

Special Issue Information

Dear Colleagues,

Frailty is a complex clinical syndrome characterized by a decline in physiological reserves and reduced homeostatic capacity, which limits the body’s ability to respond effectively to internal or external stressors. As the global population ages, frailty is becoming a major public health concern, frequently associated with repeated hospital admissions, prolonged hospital stays, reduced quality of life, and increased healthcare costs. Frequent hospitalizations among older adults often signal the progression of frailty and are predictive of disability and mortality.

We are pleased to invite you to contribute to this Special Issue of Diseases, which aims to explore the multifaceted relationship between frailty and frequent hospitalizations in older populations. This topic lies at the intersection of geriatrics, internal medicine, public health, and healthcare policy, aligning closely with the journal’s multidisciplinary scope. Our goal is to gather high-quality, evidence-based insights into risk assessment, early detection, and targeted interventions that may reduce hospital readmissions and improve the care of frail elderly patients.

In this Special Issue, original research articles and systematic or narrative reviews are welcome. Research areas may include (but are not limited to) the following:

  • Epidemiology of frailty and hospital readmissions;
  • Clinical risk factors and biomarkers of frequent hospitalizations;
  • Multidisciplinary approaches to frailty management;
  • Nutrition, lifestyle, and functional interventions;
  • Transitional care and hospital-at-home models;
  • Pharmacological and non-pharmacological strategies;
  • Policy and health system innovations in elderly care.

We look forward to hearing from you.

Dr. Francesco Ragusa
Dr. Nicola Veronese
Guest Editors

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Keywords

  • frailty
  • hospital readmissions
  • aging
  • geriatric care
  • interventions
  • risk factors
  • transitional care
  • older adults
  • healthcare utilization
  • multimorbidity

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Published Papers (1 paper)

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Research

11 pages, 706 KB  
Article
Revolving Door in Older Patients: An Observational Study of Risk Assessment of Rehospitalization Using the BRASS Scale
by Francesco Saverio Ragusa, Anna La Vattiata, Antonio Terranova, Giuseppina Pesco, Davide Mariani, Ligia J. Dominguez, Nicola Veronese, Pasquale Mansueto and Mario Barbagallo
Diseases 2025, 13(10), 325; https://doi.org/10.3390/diseases13100325 - 1 Oct 2025
Viewed by 326
Abstract
Introduction: The “revolving” door is a phenomenon that refers to the rehospitalization of older patients who, after being discharged, soon require specialized hospital care again. Unfortunately, the use of tools able to predict this phenomenon is still limited. The aim of this [...] Read more.
Introduction: The “revolving” door is a phenomenon that refers to the rehospitalization of older patients who, after being discharged, soon require specialized hospital care again. Unfortunately, the use of tools able to predict this phenomenon is still limited. The aim of this study was to highlight the validity of the Blaylock Risk Assessment Screening (BRASS) Scale in objectively assessing the risk of rehospitalization and mortality among older patients. Methods: Patients were classified as low, medium, or high risk using the BRASS scale. Adverse events (rehospitalization or death) were recorded at baseline and at 12 months. Kaplan–Meier curves evaluated survival and rehospitalization across risk groups, and ROC analysis assessed the BRASS Scale’s predictive value for mortality. Results: Out of 179 enrolled older adults (mean age 67.7 years), 54.2% were classified as low risk, 29.5% as medium, and 16.8% as high risk based on the BRASS Scale. High-risk patients had significantly higher mortality (HR: 4.40; 95% CI: 1.60–12.19, p = 0.004) and lower survival rates, while intermediate-risk patients had increased rehospitalization (HR: 2.11; 95% CI: 1.09–4.08, p = 0.02). The BRASS scale showed good predictive value for mortality (AUC 0.76). Conclusion: The BRASS Scale has a good predictive value for negative outcomes, and it confirms that a substantial proportion of older patients are at risk of future hospital readmissions and complex discharges. These findings underscore the importance of early post-discharge care planning and the implementation of protected discharge programs. Full article
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