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Nutrients
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Role of Bioactive Compounds in Oxidative Stress and Inflammation
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Role of Bioactive Compounds in Oxidative Stress and Inflammation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 5 November 2026 | Viewed by 2622

Special Issue Editors

Dr. Maria Alexandra Bernardo

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Guest Editor
Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, Portugal
Interests: clinical design: methodologies and tools validation; food chemistry: antioxidants and related compounds; health data analysis; environmental health; neurodegenerative disease and handwriting
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Leonor Silva

E-Mail Website
Guest Editor
1. Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Campus Universitário, Monte de Caparica, Caparica, Portugal
2. GENA (Applied Nutrition Research Group), School of Health & Science, Campus Universitário, Monte de Caparica, Caparica, Portugal
Interests: clinical nutrition; dietary strategies for metabolic diseases; nutrition in rheumatic disease; metabolism of plant bioactive compounds and health benefits; oxidative stress; diabetes mellitus
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue titled "Role of Bioactive Compounds in Oxidative Stress and Inflammation" in the Nutrients journal explores the intricate relationship between bioactive compounds and their potential to modulate oxidative stress and inflammatory responses. Oxidative stress, caused by an imbalance between reactive oxygen species and antioxidants, is involved in various chronic diseases, including cardiovascular disorders, diabetes, and neurodegenerative conditions. Research in this field has increasingly highlighted the protective roles of dietary bioactive compounds—such as polyphenols, flavonoids, and carotenoids—found in fruits, vegetables, and other natural sources. This Special Issue aims to shed light on the mechanisms by which these compounds exert their beneficial effects on health, focusing on their antioxidant properties, anti-inflammatory actions, and potential in disease prevention and management. Key areas of interest include the bioavailability of these compounds, their interactions within biological systems, and emerging therapeutic applications. By consolidating current findings, this Special Issue aims to advance understanding and promote further research on the use of bioactive compounds as an effective strategy to combat oxidative stress and inflammation.

Dr. Maria Alexandra Bernardo
Dr. Maria Leonor Silva
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • bioactive compounds
  • oxidative stress
  • inflammation
  • antioxidants
  • polyphenols
  • flavonoids
  • flavonoids
  • dietary supplements
  • chronic diseases
  • bioavailability
  • therapeutic applications
 

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Published Papers (2 papers)

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Research

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21 pages, 9555 KB  
Article
Rutin as a Circadian Modulator Preserves Skeletal Muscle Mitochondrial Function and Reduces Oxidative Stress to Protect Against D-Galactose-Induced Aging In Vitro and In Vivo
by Yoonha Choi, Suhyeon Lee and Eunju Kim
Nutrients 2025, 17(22), 3571; https://doi.org/10.3390/nu17223571 - 15 Nov 2025
Viewed by 1600
Abstract
Background: Skeletal muscle aging is characterized by impaired myogenic differentiation, disrupted circadian rhythms, elevated oxidative stress, and mitochondrial dysfunction. Rutin, a natural flavonoid with antioxidant properties, has been suggested to mitigate aging processes; however, its effects on circadian regulation and muscle homeostasis remain [...] Read more.
Background: Skeletal muscle aging is characterized by impaired myogenic differentiation, disrupted circadian rhythms, elevated oxidative stress, and mitochondrial dysfunction. Rutin, a natural flavonoid with antioxidant properties, has been suggested to mitigate aging processes; however, its effects on circadian regulation and muscle homeostasis remain unclear. Methods: In vitro, differentiated C2C12 myotubes were treated with D-galactose (D-gal, 20 g/L) with or without rutin (20 μM). In vivo, C57BL/6 mice were supplemented with rutin (100 mg/kg b.w.) via oral gavage in a D-gal-induced aging mouse model (150 mg/kg b.w., i.p.). Results: D-gal induced cellular senescence, impaired myogenic differentiation, disrupted circadian oscillations, increased oxidative stress, and compromised mitochondrial function. Rutin treatment restored myotube formation, enhanced circadian rhythmicity of differentiation-related genes, and corrected the antiphase patterns of Per2 and Rorc. It also reduced reactive oxygen species and malondialdehyde levels; increased superoxide dismutase, catalase, and glutathione peroxidase activity; improved ATP production and membrane potential; and decreased mitochondrial oxidative aging, as confirmed by pMitoTimer imaging. Furthermore, rutin reinstated the rhythmic expression of oxidative phosphorylation proteins and Pgc1α. In vivo, rutin supplementation enhanced muscle performance (prolonged hanging time) and oxidative capacity, particularly at night (ZT14–ZT16), without altering muscle fiber-type distribution, and normalized circadian rhythmicity of core clock genes. Conclusions: Rutin attenuates D-gal-induced cellular senescence by modulating circadian rhythms, reducing oxidative stress, and improving mitochondrial function. Importantly, its in vivo effects on muscle performance and circadian regulation suggest that rutin is a promising therapeutic strategy to counteract skeletal muscle aging and sarcopenia. Full article
(This article belongs to the Special Issue Role of Bioactive Compounds in Oxidative Stress and Inflammation)
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Review

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24 pages, 1108 KB  
Review
Novel Strategy for Cancer Therapy Proposal Based on Effects and Mechanisms of Targeting Cuproptosis by Polyphenols—A Narrative Review
by Xilong Liu, Mengyao Song, Di Ma, Yiming Pan, Xinqi Liu and Lu Li
Nutrients 2026, 18(6), 917; https://doi.org/10.3390/nu18060917 - 14 Mar 2026
Viewed by 674
Abstract
As a novel form of cell death, the discovery of cuproptosis presents significant opportunities and challenges for the field of cancer therapy. Notably, polyphenolic compounds have attracted considerable research attention for their ability to induce cuproptosis. These natural compounds not only exhibit marked [...] Read more.
As a novel form of cell death, the discovery of cuproptosis presents significant opportunities and challenges for the field of cancer therapy. Notably, polyphenolic compounds have attracted considerable research attention for their ability to induce cuproptosis. These natural compounds not only exhibit marked anti-inflammatory and antioxidant properties, but their polyhydroxy structures also enable effective chelation and transport of copper ions. This provides novel insights into cuproptosis-mediated cancer therapy. Therefore, in this review, we systematically outline copper metabolism, the mechanisms of cuproptosis, and its association with cancer, while providing an in-depth discussion of the effects and mechanisms by which polyphenolic compounds act as copper ionophores to inhibit tumor growth and progression through the induction of cuproptosis. This review indicates the promising potential of polyphenolic compounds in the field of cancer therapy and provides a theoretical basis for therapeutic strategies based on cuproptosis. Full article
(This article belongs to the Special Issue Role of Bioactive Compounds in Oxidative Stress and Inflammation)
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