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Dietary Considerations for the Prevention and Management of Liver Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 8378

Special Issue Editors


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Guest Editor
Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica, Santiago 8330024, Chile
Interests: lipid metabolism; food intake patterns; Mediterranean diet; nutrition in health and disease

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Guest Editor
Departamento de Gastroenterología, Escuela de Medicina. Pontificia Universidad Católica de Chile, Santiago 8330077, Chile
Interests: bile acid metabolism; metabolic dysfunction-associated fatty liver disease, alcoholic hepatitis; hepatocellular cancer

Special Issue Information

Dear Colleagues,

“Let food be thy medicine”

Since ancient times, healthy foods and balanced nutrition have been considered as key therapeutic tools in medicine. Indeed, diet is explicitly mentioned as a useful salutogenic measure in the Corpus Hippocraticum and the Hippocratic oath.

Regarding etiopathogenesis, clinical manifestations, progression, and treatment prospects, eating patterns and nutritional status are critical factors in a variety of liver disorders. These associations are relevant not only in acute conditions (e.g., acute liver failure), but also in chronic liver diseases (e.g., cirrhosis and its complications). Furthermore, nutritional assessment and interventions in patients with hepatic conditions are important as supportive and adjuvant approaches, but they may also be a key therapeutic determinant for some specific conditions (e.g., metabolic dysfunction-associated fatty liver disease). Despite these significant relationships, major gaps in knowledge and practice remain between nutrition and hepatology.

In this Special Issue of Nutrients, we will address several important aspects of this interdisciplinary biomedical field based on new and clinically relevant information that may impact patient care, as well as lead to novel opportunities for research and discovery.

Among others, potential topics to be considered for publication in this issue are:

  • Weight loss interventions/dietary patterns and components/plant-based foods and their bioactive compounds in nonalcoholic fatty liver disease;
  • Nutritional assessment and management of liver cirrhosis in compensated and decompensated states;
  • Enteral versus parenteral nutrition in acute and acute-on-chronic liver failure;
  • Phytosterols/Omega-3 PUFA in nonalcoholic fatty liver disease;
  • Probiotics and dietary interventions in hepatic encephalopathy;
  • Combating sarcopenia in liver disease;
  • Nutritional supplementation after liver transplantation.

Prof. Dr. Attilio Rigotti
Prof. Dr. Marco Arrese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver
  • liver cirrhosis
  • acute liver failure
  • nonalcoholic fatty liver disease
  • NAFLD
  • hepatic encephalopathy
  • hepatitis
  • hepatocellular
  • metabolism
  • diet
  • nutrition
  • bioactive compounds
  • nutritional assessment
  • phytosterols
  • Omega-3 PUFA
  • probiotics
  • sarcopenia

Published Papers (3 papers)

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Research

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15 pages, 1647 KiB  
Article
Synergistic Effect of Diet and Physical Activity on a NAFLD Cohort: Metabolomics Profile and Clinical Variable Evaluation
by Francesco Maria Calabrese, Giuseppe Celano, Caterina Bonfiglio, Angelo Campanella, Isabella Franco, Alessandro Annunziato, Gianluigi Giannelli, Alberto Ruben Osella and Maria De Angelis
Nutrients 2023, 15(11), 2457; https://doi.org/10.3390/nu15112457 - 25 May 2023
Cited by 2 | Viewed by 1416
Abstract
Together with its comorbidities, nonalcoholic fatty liver disease (NAFLD) is likely to rise further with the obesity epidemic. However, the literature’s evidence shows how its progression can be reduced by the administration of calorie-restrictive dietary interventions and physical activity regimens. The liver function [...] Read more.
Together with its comorbidities, nonalcoholic fatty liver disease (NAFLD) is likely to rise further with the obesity epidemic. However, the literature’s evidence shows how its progression can be reduced by the administration of calorie-restrictive dietary interventions and physical activity regimens. The liver function and the gut microbiota have been demonstrated to be closely related. With the aim of ascertaining the impact of a treatment based on the combination of diet and physical activity (versus physical activity alone), we recruited 46 NAFLD patients who were divided into two groups. As a result, we traced the connection between volatile organic compounds (VOCs) from fecal metabolomics and a set of statistically filtered clinical variables. Additionally, we identified the relative abundances of gut microbiota taxa obtained from 16S rRNA gene sequencing. Statistically significant correlations emerged between VOCs and clinical parameters, as well as between VOCs and gut microbiota taxa. In comparison with a physical activity regimen alone, we disclose how ethyl valerate and pentanoic acid butyl ester, methyl valerate, and 5-hepten-2-one, 6-methyl changed because of the positive synergistic effect exerted by the combination of the Mediterranean diet and physical activity regimens. Moreover, 5-hepten-2-one, 6-methyl positively correlated with Sanguinobacteroides, as well as the two genera Oscillospiraceae-UCG002 and Ruminococcaceae UCG010 genera. Full article
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Review

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21 pages, 1020 KiB  
Review
Nutritional Support for Liver Diseases
by Dominika Jamioł-Milc, Anna Gudan, Karolina Kaźmierczak-Siedlecka, Joanna Hołowko-Ziółek, Dominika Maciejewska-Markiewicz, Katarzyna Janda-Milczarek and Ewa Stachowska
Nutrients 2023, 15(16), 3640; https://doi.org/10.3390/nu15163640 - 19 Aug 2023
Cited by 3 | Viewed by 4358
Abstract
The liver is a key organ that is responsible for the metabolism of proteins, fats, and carbohydrates and the absorption and storage of micronutrients. Unfortunately, the prevalence of chronic liver diseases at various stages of advancement in the world population is significant. Due [...] Read more.
The liver is a key organ that is responsible for the metabolism of proteins, fats, and carbohydrates and the absorption and storage of micronutrients. Unfortunately, the prevalence of chronic liver diseases at various stages of advancement in the world population is significant. Due to the physiological function of the liver, its dysfunction can lead to malnutrition and sarcopenia, and the patient’s nutritional status is an important prognostic factor. This review discusses key issues related to the diet therapy of patients with chronic liver diseases, as well as those qualified for liver transplantation and in the postoperative period. Full article
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22 pages, 414 KiB  
Review
Current Insights Regarding Intestinal Failure-Associated Liver Disease (IFALD): A Narrative Review
by Marija Zafirovska, Aleksandar Zafirovski and Nada Rotovnik Kozjek
Nutrients 2023, 15(14), 3169; https://doi.org/10.3390/nu15143169 - 17 Jul 2023
Cited by 3 | Viewed by 2194
Abstract
Intestinal failure-associated liver disease (IFALD) is a spectrum of liver disease including cholestasis, biliary cirrhosis, steatohepatitis, and gallbladder disease in patients with intestinal failure (IF). The prevalence of IFALD varies considerably, with ranges of 40–60% in the pediatric population, up to 85% in [...] Read more.
Intestinal failure-associated liver disease (IFALD) is a spectrum of liver disease including cholestasis, biliary cirrhosis, steatohepatitis, and gallbladder disease in patients with intestinal failure (IF). The prevalence of IFALD varies considerably, with ranges of 40–60% in the pediatric population, up to 85% in neonates, and between 15–40% in the adult population. IFALD has a complex and multifactorial etiology; the risk factors can be parenteral nutrition-related or patient-related. Because of this, the approach to managing IFALD is multidisciplinary and tailored to each patient based on the etiology. This review summarizes the current knowledge on the etiology and pathophysiology of IFALD and examines the latest evidence regarding preventative measures, diagnostic approaches, and treatment strategies for IFALD and its associated complications. Full article
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