nutrients-logo

Journal Browser

Journal Browser

Natural Functional Factors and Chronic Diseases: Dose-Effect Relationship and Mechanism

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 March 2023) | Viewed by 2262

Special Issue Editors

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310058, China
Interests: food microbe; human diseases; bioactive components; probiotics; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Tea Research Institute, Zhejiang University, Hangzhou 310058, China
Interests: food chemistry; food functional factors; polyphenols; polysaccharides; tea compound
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products such as polyphenolic, prebiotics, probiotics, polysaccharides, etc. have brought about a promising future for chronic diseases, with studies confirming that these natural-derived components play roles in diverse chronic disorders and diseases, including gastrointestinal diseases, neurodegenerative diseases, coronary atherosclerosis, obesity, diabetes, and so on. Continuous efforts are in need to uncover more components, understand their dose–effect relationship, and elucidate their health beneficial mechanism. This Special Issue focuses on the interaction between natural functional factors and their beneficial effects on chronic diseases, especially their dose–effect relationship and mechanism. Reviews and research articles are both warmly welcomed.

Dr. Yonglu Li
Dr. Qiang Chu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural functional factors
  • chronic diseases
  • dose–effect relationship
  • mechanism

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

24 pages, 9270 KiB  
Article
Effects of Varying Ratios of Glycyrrhiza uralensis and Donkey Hide Gelatin Water Extracts on Dinitrochlorobenzene-Induced Atopic Dermatitis in NC/Nga Mice
by Linsha Dong, Ju Hyun Lee, Eun Heui Jo, Jin-Sil Lee, Seung-Hyung Kim, Dong-Sung Lee and Min Cheol Park
Nutrients 2023, 15(9), 2094; https://doi.org/10.3390/nu15092094 - 26 Apr 2023
Viewed by 1953
Abstract
Atopic dermatitis is a chronic skin disease that affects millions of people all over the world. The objective of this study was to evaluate the inhibitory effects of the roots of Glycyrrhiza uralensis (GU) and Donkey Hide Gelatin (DHG) water extracts on DNCB-induced [...] Read more.
Atopic dermatitis is a chronic skin disease that affects millions of people all over the world. The objective of this study was to evaluate the inhibitory effects of the roots of Glycyrrhiza uralensis (GU) and Donkey Hide Gelatin (DHG) water extracts on DNCB-induced NC/Nga mice and TNF-α/IFN-γ treated keratinocytes or LPS-stimulated macrophages. The combined treatment using the water extracts of GU and DHG improved the skin symptom evaluation score and skin histology, with increased expression of the skin barrier proteins Claudin 1 and Sirt 1 in lesion areas. The IFN-γ activity was promoted in PBMCs, ALN, and dorsal skin tissue, while the absolute cell number was reduced for T cells so that the production and expression of serum IgE and cytokines were suppressed. In TNF-α/IFN-γ induced HaCaT cells, IL-6, IL-8, MDC, and RANTES were all inhibited by GU and DHG water extracts, while ICAM-1 and COX-2 levels were similarly downregulated. In addition, GU and DHG water extracts decreased LPS-mediated nitric oxide, IL-6, TNF-α, and PGE2 in RAW 264.7 cells, and the expression of iNOS and COX-2 also decreased. Notably, the DHG:GU ratio of 4:1 was shown to have the best effects of all ratios. In conclusion, GU and DHG have anti-skin inflammatory potentials that can be used as alternative ingredients in the formula of functional foods for people with atopic dermatitis. Full article
Show Figures

Graphical abstract

Back to TopTop