Polyphenols and the Microbiota–Host Axis: Mechanisms of Inflammation Modulation and Cellular Protection
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".
Deadline for manuscript submissions: 20 July 2026 | Viewed by 1700
Editors
Interests: health; polyphenols; erythrocyte; antioxidants; gut microbiota
Special Issues, Collections and Topics in MDPI journals
Interests: polyphenols; oxidative stress; natural molecules; adjuvants in chemotherapy; DNA methylation; post-translational modifications of proteins
Special Issue Information
Dear Colleagues,
Dietary polyphenols, which are abundant in fruits, vegetables, cereals, tea, and wine, are powerful bioactive compounds with significant health implications. These natural compounds exert their beneficial effects through three interconnected mechanisms: modulating inflammatory pathways, protecting cellular structures from oxidative damage, and regulating the composition and function of the gut microbiota. A growing body of evidence indicates that polyphenol-induced alterations of the gut microbial ecosystem can trigger secondary metabolic pathways, amplifying their health-promoting effects beyond direct antioxidant activity.
This Special Issue aims to gather innovative, multidisciplinary research exploring the specific mechanisms by which dietary polyphenols modulate inflammation, enhance cellular resilience, and reshape the gut microbiota, thus contributing to the prevention and management of chronic diseases. We seek to integrate molecular and mechanistic studies, clinical investigations of biomarkers related to inflammatory status and cellular protection, and epidemiological evidence linking polyphenol consumption with improved health outcomes. By advancing understanding of polyphenol–microbiota–host interactions, this Special Issue aims to support evidence-based nutritional strategies and promote the rational development of polyphenol-based therapeutic approaches in health maintenance and disease prevention.
Dr. Pasquale Perrone
Dr. Laura Mosca
Guest Editors
Manuscript Submission Information
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Keywords
- dietary polyphenols
- inflammation modulation
- cellular protection
- gut microbiota
- anti-inflammatory effects
- oxidative stress defense
- microbiota-derived metabolites
- chronic disease prevention
- molecular mechanisms
- nutritional
- bioactive compounds
- polyphenol bioavailability
- host-microbiota interactions
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