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Role of Food-Derived Bioactives in Cognitive Function, Mental Health, and Healthy Aging: A Nutritional Neuroscience Perspective

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Neuro Sciences".

Deadline for manuscript submissions: 5 October 2026 | Viewed by 2282

Editors


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Guest Editor
1. Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary
2. Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary
3. Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary
Interests: nutritional neuroscience; healthy aging; cognitive function; brain health; food-derived bioactives; phytochemicals; polyphenols; neuroprotection

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Guest Editor Assistant
1. Institute of Preventive Medicine and Public Health, Semmelweis University, 1085 Budapest, Hungary
2. Fodor Center for Prevention and Healthy Aging, Semmelweis University, 1085 Budapest, Hungary
Interests: nutritional epidemiology; aging and longevity; cognitive aging; dietary interventions; brain–metabolism interactions; oxidative stress; inflammation; mental health and nutrition

Special Issue Information

Dear Colleagues,

The relationship between nutrition and brain function has emerged over the past decade as one of the most rapidly advancing areas in biomedical and public health research. Growing scientific evidence indicates that naturally occurring food-derived bioactive compounds may play a key role in maintaining cognitive function, supporting mental health, and promoting healthy aging processes. The integrative framework of nutritional neuroscience enables the combined investigation of molecular mechanisms, clinical outcomes, and population-level health effects.

This Special Issue aims to offer a comprehensive overview of the rapidly evolving interdisciplinary field of nutritional neuroscience, with a core focus on the role of food-derived bioactives in brain health, neurocognitive function, and psychological well-being across the lifespan. Aligned with a major international research priority for aging societies, we place special emphasis on mechanistic, clinical, epidemiological, and nutritional intervention studies that drive the development of evidence-based dietary recommendations and preventive strategies for lifelong brain health.

Spanning fundamental research, clinical medicine, public health, and nutritional science, this topic builds a broad author and readership base. Its multidisciplinary scope welcomes diverse methodological approaches, elevating the scientific impact of contributions and advancing collective understanding of how nutrition shapes brain health across all life stages.

We invite original research articles, narrative and systematic reviews, and meta-analyses addressing the interactions between nutrition, brain health, and healthy aging, including (but not limited to) research from basic, clinical, and epidemiological fields, as well as dietary intervention studies. All submissions will advance the development of evidence-based nutritional strategies to support lifelong brain health.

Dr. Mónika Fekete
Guest Editor

Dr. Noémi Mózes
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional neuroscience
  • healthy aging
  • food-derived bioactives
  • polyphenols
  • dietary patterns
  • Mediterranean diet
  • cognitive decline
  • neurodegeneration
  • mental health
  • neuroinflammation
  • oxidative stress
  • gut–brain axis
  • psychobiotics
  • precision nutrition

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Published Papers (1 paper)

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Review

36 pages, 1187 KB  
Review
Dietary Polyphenols in Brain Aging: Molecular Mechanisms and Implications for Neurodegeneration
by Noémi Mózes, János Tamás Varga, Dominik Szwajgier, Agata Kryczyk-Poprawa, Virág Zábó, Andrea Lehoczki, Ágnes Lipécz, Tamás Csípő, Vince Fazekas-Pongor, Dávid Major, Péter Varga, Attila Matiscsák and Mónika Fekete
Nutrients 2026, 18(9), 1470; https://doi.org/10.3390/nu18091470 - 5 May 2026
Cited by 1 | Viewed by 1954
Abstract
Background/Objectives: Population aging is accompanied by a rapidly increasing burden of neurodegenerative disorders, particularly Alzheimer’s and Parkinson’s diseases. Within the geroscience framework, targeting fundamental mechanisms of aging may delay the onset or progression of multiple age-related conditions. Dietary factors, especially plant-derived polyphenols, have [...] Read more.
Background/Objectives: Population aging is accompanied by a rapidly increasing burden of neurodegenerative disorders, particularly Alzheimer’s and Parkinson’s diseases. Within the geroscience framework, targeting fundamental mechanisms of aging may delay the onset or progression of multiple age-related conditions. Dietary factors, especially plant-derived polyphenols, have gained increasing attention due to their potential to modulate molecular pathways involved in brain aging. This narrative review aims to integrate current evidence on dietary polyphenols and their role in modulating the molecular mechanisms underlying brain aging and neurodegeneration. Methods: This narrative review synthesizes findings from molecular, experimental, epidemiological, and clinical studies to provide an integrated assessment of the effects of dietary polyphenols on key cellular pathways involved in brain aging. Results: Polyphenols are widely present in plant-based foods, and polyphenol-rich dietary patterns—particularly the Mediterranean and MIND diets—have been consistently associated in observational studies with a reduced risk of cognitive decline. Mechanistic evidence, derived predominantly from in vitro and animal studies with limited validation in humans, suggests that polyphenols may influence key hallmarks of aging, including oxidative stress, chronic inflammation, mitochondrial dysfunction, cellular senescence, and impaired proteostasis. These effects are mediated through pathways such as Nrf2, NF-κB, AMPK, mTOR, and SIRT1, as well as via gut–brain axis interactions. However, clinical evidence remains heterogeneous. Conclusions: Dietary polyphenols represent a biologically plausible and promising, yet not fully validated, nutritional strategy for promoting healthy brain aging. Their translation into clinical practice is limited by low bioavailability, substantial interindividual variability, and the lack of large-scale, long-term randomized controlled trials. Full article
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