Special Issue "Non-Coding RNA and Brain Tumors"
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: closed (1 December 2018).
Interests: ncRNAs; exosomes and extracellular vesicles; tumor heterogenity; stem cells
Special Issues and Collections in MDPI journals
Brain tumors, as other cancers, are complex genetic diseases involving expressional abnormalities of both protein-coding and non-coding genes. Together, they form complex RNA networks within the molecular microcosm, which are not fully recognized yet.
Considering that protein-coding genes constitute only small fraction of human genome, researchers increasingly switched their focus toward non-protein-coding transcriptome that may provide vast panoply of targets for anti-cancer therapy.
In fact, non-coding RNA (ncRNA) is much more than the mundane messenger between DNA and the protein—it springs up into multiple species (including long non-coding RNAs (lncRNAs), microRNAs or circular RNAs (circRNAs)). Differences between cells during normal development and pathogenesis are in many cases due to differences in when, where and how genes are turned on or off.
It is believed that ncRNAs play enormous role in these processes by facilitating or impeding transcription, translation and activity of protein-coding genes and their products. Additional layers of complexity are the microenvironmental rearrangements contributing to intra-tumoral heterogeneity inducing abnormalities/alteration of gene expression via cellular and acellular (exosomal) ncRNA.
In this Special Issue of Non-coding RNA we invite many experts in the field of brain tumor to present their point of view on various aspects of ncRNA function, regulation and therapeutic advances.
Dr. Agnieszka M Bronisz
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- primary and metastatic brain tumor
- tumor microenvironment
- tumor heterogeneity exosomes
- therapeutic targeting and delivery
- stem cells