Special Issue "Nanoparticle-Macrophage Interactions: Implications for Nanosafety and Nanomedicine"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: 20 October 2020.
2. University of Helsinki, HiLIFE unit Helsinki, Finland
Interests: nanoparticles; antibacterial nanoparticles; nanotoxicology; cell-nanoparticle interactions; nanoparticle-mediated drug delivery
2. IRCCS Istituto Clinico Humanitas, Via A. Manzoni 56, 20089 Rozzano, Milan, Italy
Interests: nanoparticles; macrophages; monocytes; innate immune system; immunotoxicity; cell death; surface functionalization; immunotherapy; macrophage-nanoparticle interaction
Nanoparticles (NPs) offer unique physicochemical properties useful for biomedical applications, e.g., as antibacterials, vaccine adjuvants, and bioimaging and/or antitumoral agents. Medical use of NPs commonly implies their injection into the bloodstream, but other routes have been explored, such as the subcutaneous, oral, intranasal, inhalation or transdermal administration. Once in the body, NPs are inevitably recognized by the immune system. Macrophages are a major class of phagocytic innate immune cells, specializing in the neutralization and/or uptake of foreign material (including NPs) and consequent mounting of an immunological response. The mechanisms implicated in the uptake of NPs by macrophages determine the lifetime of NPs in relevant biological fluids or tissues, which has consequences for their nanosafety and biomedical applications. Various safe-by-design strategies, such as pegylation and other surface functionalizations of NPs, have been implemented to manipulate the recognition of NPs by monocytes/macrophages and, thus, their immunotoxicological properties. Of note, NPs have been also designed on purpose to target macrophages with the aim to trigger or to inhibit immune responses, for example, killing or reprogramming the tumor associated macrophages.
The aim of the current Special Issue is to cover recent advancements in our understanding of NP-macrophage interactions using in vitro, in vivo, and in silico approaches, novel strategies to control the toxicological and immunological profile of NPs, and innovative ways to modulate the delivery of NPs towards macrophages for safety and medical purposes.
Dr. Olesja Bondarenko
Dr. Fernando Torres Andón
Manuscript Submission Information
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- surface functionalization
- macrophage–nanoparticle interaction