Special Issue "Nanonutraceuticals Delivery"

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Dr. Luciana Dini
Website
Guest Editor
Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, 00185 Rome, Italy
Interests: magnetic fields; cell death (apoptosis, autophagy, necroptosis, ferroptosis); nanomaterials; natural medicine
Dr. Cristian Vergallo
Website
Guest Editor
Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", 63100 Chieti, Italy
Interests: magnetic fields; apoptosis and phagocytosis; nanomaterials; plant-based natural compounds; plant and human nutrition

Special Issue Information

Dear Colleagues,

Among the many nanotechnology applications, there is the production of nanoscale materials for the food industry by the characterization, fabrication, and manipulation of structures, devices or materials having at least one dimension not exceeding 100 nm. The science of nanosized food ingredients has made great progress in the last few years, with products that increase the functionality or bioavailability of nutrients, thereby minimizing their concentrations needed in the marketed foods. Nevertheless, the production of nanodelivered nutraceuticals is still in its infancy. In addition to their actual function of providing nutrition, some obtained in vitro outcomes show these pharmaceutical-grade and standardized nanonutrients have health benefits by preventing the occurrence of cancers and several cardiovascular and neurodegenerative disorders. However, their safe nanomaterials-based delivery without exhibiting any side effects for humans is a matter of discussion in the scientific community.

The Special Issue aims to provide further knowledge in the field of application of nanomaterial-based carriers involved in nutraceutical delivery through original articles and reviews focused on the development of innovative synthesis processes, as well as in vitro and in vivo studies assessing the biological effects and/or physical and chemical properties of them.

Potential topics include but are not limited to the following:

  • Delivery of nanonutraceuticals;
  • Dietary nanosupplements;
  • Food nanoadditives;
  • Food nanomaterials;
  • Functional nanofoods;
  • Nanoencapsulation of nutraceuticals and nutrients;
  • Nanoformulations including nutraceuticals;
  • Pharmaceutical-grade and standardized nanonutrients.

Dr. Luciana Dini
Dr. Cristian Vergallo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Delivery of nanonutraceuticals
  • Dietary nanosupplements
  • Food nanoadditives
  • Food nanomaterials
  • Functional nanofoods
  • Nanoencapsulation of nutraceuticals and nutrients
  • Nanoformulations including nutraceuticals
  • Pharmaceutical-grade and standardized nanonutrients

Published Papers (1 paper)

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Research

Open AccessArticle
Nanoemulgel for Improved Topical Delivery of Retinyl Palmitate: Formulation Design and Stability Evaluation
Nanomaterials 2020, 10(5), 848; https://doi.org/10.3390/nano10050848 - 28 Apr 2020
Abstract
Retinyl palmitate is a vitamin A ester belonging to the family of endogenous natural retinoid and used to treat various skin disorders like acne, skin aging, wrinkles, and dark spots, as well as to protect against psoriasis. Despite the known therapeutic benefits of [...] Read more.
Retinyl palmitate is a vitamin A ester belonging to the family of endogenous natural retinoid and used to treat various skin disorders like acne, skin aging, wrinkles, and dark spots, as well as to protect against psoriasis. Despite the known therapeutic benefits of retinyl palmitate, the conventional topical delivery of retinyl palmitate commonly associated with adverse reactions such as skin irritation, redness, excessive peeling, and dryness. Therefore, the current study aims to encapsulate the retinyl palmitate in nanoemulsion then incorporate it into a hydrogel system to improve the topical delivery and stability. Low-energy emulsification method was used for the nano-encapsulation of retinyl palmitate. The phase behavior study was used for the investigation and the optimization of the formulation. The droplet size of the optimized nanoemulsion was in nano dimension (16.71 nm) with low polydispersity index (PdI) (0.015), negative zeta potential (−20.6 mV). It demonstrated the influence of vortexing on droplet size and PdI during nanoemulsion preparation. The retinyl palmitate loaded nanoemulgel delivery system exhibited significant improvement (p < 0.05) in skin permeability after topical application. Employment of the nano-encapsulation approach afterward dispersion into hydrogel system for the development of a topical delivery system of retinyl palmitate resulted in improvement in its UV and storage stability as well. Full article
(This article belongs to the Special Issue Nanonutraceuticals Delivery)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases
Authors: Cristian Vergallo
Affiliation: Department of Biological and Environmental Science and Technology (Di.S.Te.B.A.), University of Salento, Lecce, Italy; [email protected]
Abstract: Scientific community is becoming increasingly interested in identifying, characterizing, and delivering nutraceuticals. Despite their traditional role in human nutrition, these bioactive agents, which in the global marketplace have become a multi-billion dollars, are claimed to exhibit health benefits, including the ability to prevent/treat diseases such as arthritis, cancer, osteoporosis, cataracts, Alzheimer’s, and Huntington’s diseases, heart, brain and metabolic disorders, etc. Nutraceuticals are typically consumed as part of a regular human diet and are usually present within foods, comprising vegetable oil, although at low levels and variable composition. Thus, it is difficult to control the type, amount and frequency of their ingestion by individuals. Nanoformulations about vegetable oil-based bioactive compounds with nutraceutical properties are useful for overcoming these issues while improving the uptake, absorption, and bioavailability in the body. The purpose of this current study is to review papers on such nanoformulations, particularly those relevant for health benefits, prevention and management of diseases, as well as bioactives extracted from vegetable oils enhancing the drug effectiveness, retrieved through bibliographic databases by setting a timespan from January 2000 to April 2020 (about 1758 records).

Title: Resveratrol nano-formulation: modified surfactant-based nanocarriers to target skeletal muscle cells
Authors: CARAFA Maria; MARIANECCI Carlotta
Affiliation: Dep. of Chemistry and Technology of Drugs, Sapienza University of Rome, Rome, IT
Abstract: Oxidative stress and functional impairment of muscle-nerve communication represent a common feature of aging and several neuromuscular disorder such as ALS. Resveratrol (RV), a 14-carbon skeleton stilbene consisting of two aromatic rings with hydroxyl groups in position 3, 5, and 40 , joined by a double styrene bond, derived from red grapes, berries, and peanuts, has been subjected to considerable attention according to its several health-promoting activities. RV seems to initiate differentiation of mouse skeletal muscle-derived C2C12 myoblasts and an improvement of muscle functions in resveratrol-treated rats are good indications for an active RV concentration in muscle tissue. In this work, surfactant-based nanocarriers coated by chitosan and its derivatives have been investigated and proposed as new targeting vectors for skeletal muscle, with potential applications as RV delivery systems for modulation of myogenic differentiation. Chitosan is a polycation offering many advantages, a high degree of biodegradability and biocompatibility, as well as mucoadhesive and permeability-enhancing properties, and also large availability and relatively low cost. Dynamic light scattering was used to determine the size, zeta ()-potential, polydispersity index, polymer-coating and colloidal stability of the nano-formulations. Nanocarrier morphology have been investigated by Small Angle X-Ray Scattering (SAXS) analyses. Stability in serum of nanoarriers and release kinetics of RV have been evaluated. Nanoformulations containing a fluorescent dye have been added to C2C12 skeletal muscle cell lines to investigate cytotossicity and uptake efficiency. In conclusion, proposed nano-formulations are stable over time and in serum and showed a low toxicity and a high internalization capability.

Title: Novel therapeutic nanoformulations for curcumin delivery in Central Nervous System related disorders
Authors: Elisa Panzarini 1, Stefania Mariano 1, Stefano Tacconi 1, Elisabetta Carata 1, Ada Maria Tata 2 and Luciana Dini 2,3,*
Affiliation: 1 Dep. of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, IT 2 Dep. of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Rome, IT 3 CNR Nanotec Lecce * Correspondence: [email protected]
Abstract: Nutraceuticals represent alternative medicinal products in pharmaceutical industries. It is widely accepted their medical or health benefits in preventing or treating different types of diseases due to fewer side effects than synthetic drugs, improved bioavailability and long half-life. Among herbal and natural compounds, curcumin is a very attracting herbal supplement that can be considered as a panacea in this field. In fact, curcumin attracts a high interest due to its anti-inflammatory, antioxidant and immunomodulatory effects in cancer, cardiovascular diseases, diabetes mellitus, autoimmune diseases, and brain or psychiatric conditions. The therapeutic and protective effects of curcumin in Central Nervous System (CNS)-related disorders, such as Alzheimer and Parkinson diseases, and Glioblastoma multiforme (GBM), rely on its impact on glial cells and it is particularly interesting; however, its uptake into the brain is severely restricted by its low ability to cross the Blood-Brain Barrier (BBB). To address this problem, to increase the shelf life and delivery of curcumin in the brain and to favor its wide utilization in medicinal and pharmaceutical applications, new engineered formulations are being considered. The present review aims to summarize the current nanoformulations available in improving bioactivity of curcumin in neurological disorders.

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