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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in the Synthesis and Structural Elucidation of Bioactive Lipid Mediators

edited by Robert Nshimiyimana and

Hong Yong Peh

submission deadline 31 Jan 2026 | Viewed by 86 | Submission Open

Keywords: total synthesis; stereochemistry; resolution of inflammation; lipid mediators; structural elucidation; biosynthesis; eicosanoids; docosanoids

(This special issue belongs to the Section Organic Chemistry)

Transition Metal Complexes for Small Molecule Bond Activation

edited by

Rebeca Arevalo Seco

and

Michael Findlater

submission deadline 31 Jan 2026 | Viewed by 74 | Submission Open

Keywords: transition metal complex; bond activation; small molecule; functionalization; oxidative addition; metal– ligand and metal– metal cooperation; second coordination sphere interactions

(This special issue belongs to the Section Organic Chemistry)

Chemistry and Applications of Compounds Containing Quinoline or Isoquinoline Structure

edited by

Stanislav Kafka

and

José Carlos Menéndez

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1260 | Submission Open

Keywords: quinoline; isoquinoline; synthesis; molecular structure; alkaloids; fluorescence; green chemistry; crystal structure; structure– activity relationship; antitumor agents

(This special issue belongs to the Section Organic Chemistry)

Applied Innovative Insights in Selective Organic Hetero-Synthesis

edited by

Mircea Darabantu

and

Ionel Mangalagiu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1232 | Submission Open

Keywords: hetarenes; hetero-alycycles; regioisomerism; diastereomerism; enantiomerism; biomimetics and new chemical entities (NCEs); “ intelligent” molecules

(This special issue belongs to the Section Organic Chemistry)

Synthesis and Spectroscopic Characterization of Organometallic Compounds

edited by

Jacek Nycz

submission deadline 28 Feb 2026 | 1 articles | Viewed by 807 | Submission Open

Keywords: catalytic activity; synthesis and reactivity; spectroscopy; reaction mechanism; structural and spectroscopic characterization; turnover number (abbreviated TON); electrochemistry

(This special issue belongs to the Section Organic Chemistry)

Visible Light Active Photocatalysts for Organic Synthesis

edited by Wentao Xu

submission deadline 28 Feb 2026 | Viewed by 161 | Submission Open

Keywords: organic chemistry; photocatalyst; synthesis; radical; single-electron transfer; atom transfer; energy transfer

(This special issue belongs to the Section Organic Chemistry)

Current Topics and Applications of Chiral Auxiliaries

edited by Shawn Raynard Hitchcock

submission deadline 28 Feb 2026 | Viewed by 99 | Submission Open

Keywords: chiral auxiliary; asymmetric synthesis; diastereoselection; organic synthesis; stereochemistry; chiral control

(This special issue belongs to the Section Organic Chemistry)

Recent Advances in Radical Chemistry

edited by

Jia-Rong Chen

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: radical chemistry; radical cross-coupling; photocatalysis; electrochemical synthesis; transition metal catalysis

(This special issue belongs to the Section Organic Chemistry)

Green Organic Synthesis: Innovations for a Sustainable Future

edited by

Lu Liu

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: sustainability; organic synthesis; green chemistry; precise synthesis; chemoselectivity; regioselectivity; enantioselectivity; catalysis

(This special issue belongs to the Section Organic Chemistry)

Synthesis and Properties of Heterocyclic Compounds: Recent Advances—2nd Edition

edited by

Maria João Queiroz

submission deadline 28 Feb 2026 | Viewed by 44 | Submission Open

Keywords: heterocyclic compounds; synthesis; applications; biological activity

(This special issue belongs to the Section Organic Chemistry)

New Approaches in the Synthesis of Organophosphorus Compounds

edited by

Jakub Adamek

and

Jacek Nycz

submission deadline 10 Mar 2026 | Viewed by 89 | Submission Open

Keywords: organophosphorus chemistry; P-compounds; reactivity of P-compounds; P-C bond formation; phosphorus-based organocatalysis; phosphonium-based ionic liquids (PILs); mitochondria-targeted triphenylphosphonium-based compounds; bisphosphonates; neutralization of P-compounds; chemical warfare agents; structure elucidation of P-compounds

(This special issue belongs to the Section Organic Chemistry)

Hypervalent Iodine Chemistry: Promise and Prospects

edited by

Toshifumi Dohi

submission deadline 31 Mar 2026 | 2 articles | Viewed by 6082 | Submission Open

Keywords: hypervalent compound; iodine; new reagent and catalyst; new synthetic transformation; synthetic application; the hypervalent iodine-bearing hybrid molecule

(This special issue belongs to the Section Organic Chemistry)

Heterogeneous Catalysts: From Synthesis to Application

edited by Milan Kralik

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2131 | Submission Open

Keywords: heterogeneous catalyst; acid– base; redox; enzymatic; electrocatalytic; photocatalytic; chemical specialties; characterization methods; mathematical modelling; process design; ecology; safety; economy

(This special issue belongs to the Section Organic Chemistry)

Feature Papers in Organic Chemistry—Third Edition

edited by

Roman Dembinski

and

Jacek Nycz

submission deadline 31 Mar 2026 | Viewed by 217 | Submission Open

Keywords: organic synthesis; organic chemistry research; synthesis methods; theoretical study; reaction mechanisms; catalysis

(This special issue belongs to the Section Organic Chemistry)

Synthesis and Application of 1,2,3-Triazole Derivatives

edited by

Yubo Jiang

and

Guiping Qin

submission deadline 31 Mar 2026 | Viewed by 58 | Submission Open

Keywords: 1; 2; 3-triazoles; synthesis; modification; transannulation; application

(This special issue belongs to the Section Organic Chemistry)

Advancements in Organic Boron Chemistry

edited by Xiaodong Yin

submission deadline 31 Mar 2026 | Viewed by 35 | Submission Open

Keywords: organoboron compounds; synthesis; structural elucidation; spectroscopic studies; functional materials; catalysis and biomedical application

(This special issue belongs to the Section Organic Chemistry)

Catalysis in Organic Chemistry: A Themed Issue Dedicated to Professor Johannes G. de Vries

edited by Sergey Tin

submission deadline 16 Apr 2026 | Viewed by 73 | Submission Open

Keywords: homogeneous catalysis; enantioselective catalysis; transformation of renewable resources; industrial catalysis

(This special issue belongs to the Section Organic Chemistry)

Green and Environmentally Friendly Visible-Light- and Transition Metal-Catalyzed Synthesis

edited by

Bogdan Štefane

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4034 | Submission Open

Keywords: green synthesis; sustainable chemistry; transition metal catalysis; light induced transformations; photoredox catalysis; organic synthesis

(This special issue belongs to the Section Organic Chemistry)

Catalysis for Drug Discovery

edited by

Deyun Qian

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: organic synthesis; metal catalysis; organocatalysis; asymmetric catalysis; photocatalysis; electrocatalysis; drug discovery

(This special issue belongs to the Section Organic Chemistry)

Supramolecular Catalytic Systems Build on Macrocycle-Base Host-Guest Interactions

edited by

Xiaowei Li

submission deadline 30 Jun 2026 | Viewed by 48 | Submission Open

Keywords: supramolecular catalysis; host– guest systems; macrocycles; noncovalent interactions; microenvironments; activity; stimuli-responsiveness; enantioselectivity/selectivity; transition state stabilization; product inhibition; tandem catalysis

(This special issue belongs to the Section Organic Chemistry)

Modern Application of Cycloaddition Reactions: Experimental and Theoretical Research

edited by

Agnieszka Kącka-Zych

and Patricia Perez

submission deadline 31 Aug 2026 | 1 articles | Viewed by 643 | Submission Open

Keywords: cycloaddition reactions; molecular electron density theory; density functional theory; reaction mechanism; organic synthesis; bioactive compounds; biological activity of heterocyclic compounds

(This special issue belongs to the Section Organic Chemistry)

Advances in Alkyne Chemistry

edited by Ruimao Hua

submission deadline 25 Nov 2026 | 7 articles | Viewed by 29524 | Submission Open

Keywords: alkyne annulation; carbocycle synthesis; heterocycle synthesis; atom-economic reaction; synthesis methodology

(This special issue belongs to the Section Organic Chemistry)

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