Current Topics and Applications of Chiral Auxiliaries
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: 28 February 2026
Special Issue Editor
Special Issue Information
Dear Colleagues,
Stoichiometric chiral auxiliaries have been invaluable tools in the diastereoselective and enantioselective synthesis of a host of biologically important molecules. These chiral auxiliaries vary widely in structure and function, but all share the common theme of being synthesized from commercially available and renewable natural resources (carbohydrates and alpha-amino acids). The most successful chiral auxiliaries have been versatile in their applications through multiple classes of reactions (alkylation, aldol addition, Diels–Alder cycloadditions, and conjugate additions) and provide high levels of diastereoselection. Among the most successful chiral ligands have been Evans’ oxazolidinone and related oxazolidine-2-thione, thiazolidine-2-thione, Oppolzer’s sultam, Ender’s hydrazone, Meyer’s pseudoephedrine, and Ellman’s sulfinamide. There is ongoing research in this area, as evidenced by the use of these auxiliaries in contemporary asymmetric organic synthesis. This Special Issue solicitation seeks the submission of articles on the use of chiral auxiliaries either in the form of methodology development, the synthesis of biologically active materials, or as analytical tools in spectroscopic analysis.
Prof. Dr. Shawn Raynard Hitchcock
Guest Editor
Manuscript Submission Information
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Keywords
- chiral auxiliary
- asymmetric synthesis
- diastereoselection
- organic synthesis
- stereochemistry
- chiral control
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