Hypervalent Iodine Chemistry: Promise and Prospects

Dear Colleagues,

Halogens can be incorporated into many useful organic molecules and fine chemicals in various scientific fields, such as natural products, biologically active compounds, and organic materials. In organic synthesis, halogen-including molecules have played distinct roles as synthetic intermediates for various transformations, chemical reagents and catalysts for efficient halogen introductions, and other synthetic transformations, such as oxidations and many bond-forming reactions.

Iodine atoms in organic compounds can easily take hypervalent forms, popularly used for oxidations and many bond-forming reactions. These hypervalent iodine reagents have become important in modern organic synthesis as greener alternatives to heavy metal oxidants because of their low toxicity, mild reactivity, high stability, easy availability and handling, ease of recovery and recyclability, etc. Recently, the field of hypervalent iodine chemistry has experienced significant growth through continuous breakthroughs in this century, evidenced by the increasing number of literature publications on the subject. Hypervalent iodine catalysis and asymmetric organocatalysis in oxidative transformations are the driving forces behind this prosperity. Using hypervalent iodine reagents in transition metal-free coupling and oxidative coupling has also significantly contributed to the field. Furthermore, new strategies and concepts for their uses in organic synthesis have appeared, which involve organic transformation controlled by hypervalent iodine groups and reagents, design of new hypervalent iodine-based reagents and catalysts, effective synthesis of useful hypervalent iodine reagents and compounds, and unique synthetic intermediate bearing hypervalent iodine groups, etc. In addition, photosensitive characteristics and unique halogen bonding interaction between hypervalent iodine atoms and heteroatom groups have become a general chemical strategy in designing photoacid generators, organic materials and pharmaceutical compounds, and new Lewis acidic catalysis.

This Special Issue will highlight recent opportunities and new concepts in hypervalent iodine reagents in organic synthesis and other applications for their continuous development in future studies. We welcome reviews and original research articles associated with recent achievements. Areas to be covered in this Special Issue may include but are not limited to the extension of the known synthetic strategy and reaction for the new construction of organic molecules and for application to useful organic compounds, i.e., bioactive molecules and organic materials.

Prof. Dr. Toshifumi Dohi
Guest Editor

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• hypervalent compound
• iodine
• new reagent and catalyst
• new synthetic transformation
• synthetic application
• the hypervalent iodine-bearing hybrid molecule