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Supramolecular Catalytic Systems Build on Macrocycle-Base Host-Guest Interactions

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 437

Special Issue Editor

Key Laboratory of Radiation Physics and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
Interests: supramolecular chemistry; organic supramolecular functional materials; bionnanotechnology

Special Issue Information

Dear Colleagues,

This Special Issue explores cutting-edge advancements in supramolecular catalytic systems leveraging macrocycle-based host–guest interactions. These systems utilize macrocyclic hosts, such as crown ethers, cyclodextrins, calixarenes, cucurbiturils, and pillararenes, to create tailored microenvironments that mimic enzymatic active sites. By harnessing non-covalent interactions (e.g., hydrogen bonding, hydrophobic effects, halogen bonding, anion–π interactions, cation–π interactions, and electrostatic forces), these systems achieve remarkable enhancements in catalytic activity, selectivity, and stimulus-responsive behavior. Key themes include the design of hybrid materials integrating macrocycles with nanomaterials or polymers, applications in sustainable chemistry (e.g., C–H activation and photochemical reactions), and the role of templating strategies in guiding macrocycle formation and function. The Issue also highlights emerging trends in supramolecular catalysis, such as cooperative catalysis involving organometallic compounds, host–guest-modulated reactivity, and the use of these systems in environmental and biomedical applications.

Dr. Xiaowei Li
Guest Editor

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Keywords

  • supramolecular catalysis
  • host–guest systems
  • macrocycles
  • noncovalent interactions
  • microenvironments
  • activity
  • stimuli-responsiveness
  • enantioselectivity/selectivity
  • transition state stabilization
  • product inhibition
  • tandem catalysis

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Published Papers (1 paper)

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Research

9 pages, 1731 KB  
Article
Phenyl-Bis-Naphthyl Derivative-Based Artificial Light-Harvesting System for Singlet Oxygen Oxidation
by Liangtao Pu, Yonglei Chen and Guangping Sun
Molecules 2025, 30(22), 4424; https://doi.org/10.3390/molecules30224424 - 16 Nov 2025
Viewed by 292
Abstract
A novel artificial light-harvesting system (LHS) for the photooxidation reaction was constructed by the phenyl-bis-naphthyl derivative (PBN) and water-soluble phosphate-pillar[5]arene (WPP5). After host–guest interaction, WPP5 integrated with PBN to form WPP5-PBN amphiphiles, which self-assembled to WPP5-PBN nanoparticles. Based on [...] Read more.
A novel artificial light-harvesting system (LHS) for the photooxidation reaction was constructed by the phenyl-bis-naphthyl derivative (PBN) and water-soluble phosphate-pillar[5]arene (WPP5). After host–guest interaction, WPP5 integrated with PBN to form WPP5-PBN amphiphiles, which self-assembled to WPP5-PBN nanoparticles. Based on the aggregate state of PBN in WPP5-PBN nanoparticles, WPP5-PBN nanoparticles emitted a significant yellow fluorescence as energy donors. Due to the yellow fluorescence fully covering the absorption of sulforhodamine 101 (SR101), SR101 was used as energy acceptors and loaded in WPP5-PBN nanoparticles for constructing the WPP5-PBN-SR101 LHS, whose energy transfer efficiency and antenna effect were 66.32% and 22.34. Notably, after the energy of the WPP5-PBN antenna transferred to SR101, more singlet oxygen (1O2) production was observed in the WPP5-PBN-SR101 LHS, which was successfully used as a photocatalyst to catalyze the oxidation reaction of 4-methoxythioanisole to 1-methoxy-4-(methylsulfinyl)benzene, imitating the solar energy conversion to chemical energy. Full article
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