Special Issue "Terpenoids"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 November 2011).
Interests: natural products chemistry; synthesis of bioactive terpenoids; radical strategies; biomimetic cyclizations; new quirons as starting materials; terpenoids from fungi
Terpenoids, including more than 35.000 well defined molecules, probably constitutes the natural products family with the greater structural diversity. Numerous of these compounds possess well known applications as drugs, cosmetics, perfumes, flavours, insecticides, herbicides, phyto-hormones and many others. In recent years a number of advances in terpenoid research have led for example to the discovery of a second biosynthetic pathway, namely methyl-erythritol phosphate pathway (MEP), usually present in bacteria and plants. The knowledge of the structure of both, enzymes and genes involved in this pathway and the detailed mechanism of the specific steps are opening the possibility to develop new selective and efficient molecules with bioactivities against those pathogen micro-organisms responsible of the resistant strains from tuberculosis and malaria. Furthermore we have acquired better understanding of the structure and way of working of the key-enzymes, prenyltransferases and terpenecyclases, which are the principal motive of the uncommon molecular diversity in terpenoids. All this is provoking, among other things a develop of new research lines in order to optimize the biotechnological production of bioactive terpenes through genetic engineering from plants and microorganisms.
Moreover advances in Organic Synthesis, including new biomimetic strategies and the use of natural quirons, are reaching an important role in the development of more efficient syntheses easily scalable to industrial levels. Thus, is remarkable the appearance at antitumor medicament worldwide market of diverse diterpene taxol derivatives thanks to the sustainable farming of Taxus baccata, plant used as natural source for the terpenic backbone in combination with a semisynthetic process.
This special issue attempts to be a meeting point and a discussion forum for the interchange of experiences in terpenoid chemistry. Contributions about all the different steps involved in this field of research: extraction processes; isolation procedures; structural elucidation; direct identification from extracts by chromatographic or spectroscopic techniques; derreplication by HPLC combined with Mass Spectrometry or NMR; biotransformations; partial synthesis or total synthesis will be well received.
Prof. Dr. Alejandro Fernandez Barrero
- structural elucidation
- total synthesis