Special Issue "New Frontiers on the Metabolism, Bioavailability and Health Effects of Phenolic Compounds II"
Deadline for manuscript submissions: 30 October 2019
Dr. Rafael Llorach Asunción
Biomarkers & Nutrimetabolomic group, Nutrition, Food Sciences and Gastronomy Department, XaRTA, INSA, Campus Torribera, Pharmacy Faculty, University of Barcelona, Spain
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Interests: nutrimetabolomics; food science; nutrition; phytochemicals; phenolic compounds; food metabolome; biomarkers
We are pleased to inform you that Molecules will launch the second part of the Special Issue “New Frontiers on the Metabolism, Bioavailability and Health Effects of Phenolic Compounds”.
With a fresh set of eyes and following the standards of a realistic research, this Special Issue should shed light on how (poly)phenolic substances are: (1) metabolized and turned into bioavailable molecules and (2) able to impact different biological processes related to human health. Phenolic compounds have shown promising health promotion features concerning the prevention of non-communicable diseases in epidemiological and human intervention studies. The elucidation of the metabolic fate of (poly)phenolic constituents and their bioavailability is a tipping point for fully unraveling the bioactive(s) responsible for phenolic compounds' demonstrated preventative effects on cardiovascular diseases, metabolic syndrome, neurodegenerative disorders, and certain kinds of cancer. There is a need for addressing: (1) the catabolism of phenolic compounds by the colonic microbiota and (2) the inter-individual differences in bioavailability and bioefficacy due to the diversity of microbiota composition. Moreover, future research should be focused on: (1) understanding the dose/phenolic intake–response relationship via pharmacokinetic studies and (2) evaluating proper biomarkers of intake. The design of nutritionally matched control–test foodstuffs is also required to conduct well‑controlled intervention studies in both animals and human subjects. In vitro investigations using physiologically achievable concentrations of (poly)phenol phase II metabolites with appropriate model test systems are also encouraged to provide adequate mechanistic insights. On the other hand, foodomics technologies (metabolomics, nutrigenomics, and proteomics) should be used to assess the role of phenolic bioactives from a comprehensive perspective. Likewise, any novel food-processing approach trying to enhance the bioavailability of (poly)phenols or sticking to what really happens after phenolic consumption should be taken into consideration. Finally, new communication channels and educational programs that are able to bring to the general public the well-defined biological properties of phenolics should be implemented. In conclusion, this Special Issue should review all aspects concerning the metabolism, bioavailability, and biological properties of (poly)phenolic compounds and discuss attempts to solve current critical gaps. Novel methodologies or out-of-the-box approaches can also complement the current knowledge and assist in the study of these plant bioactives.
Dr. Pedro Mena
Dr. Rafael Llorach Asunción
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Experimental realism
- Phenolic compounds
- Dietary plant bioactives
- Colonic catabolism
- Phase II metabolites
- Gut microbiota
- Human intervention trials