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Open AccessArticle

Effect of Selected Stilbenoids on Human Fecal Microbiota

1
Department of Food Quality and Safety, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic
2
Department of Microbiology, Nutrition and Dietetics, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic
3
Institute of Animal Physiology and Genetics, CAS, v.v.i., Videnska 1083, 14220 Prague, Czech Republic
4
Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1946/1, 61242 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editors: Pedro Mena and Rafael Llorach Asunción
Molecules 2019, 24(4), 744; https://doi.org/10.3390/molecules24040744
Received: 17 January 2019 / Revised: 8 February 2019 / Accepted: 15 February 2019 / Published: 19 February 2019
Dietary phenolics or polyphenols are mostly metabolized by the human gut microbiota. These metabolites appear to confer the beneficial health effects attributed to phenolics. Microbial composition affects the type of metabolites produced. Reciprocally, phenolics modulate microbial composition. Understanding this relationship could be used to positively impact health by phenolic supplementation and thus create favorable colonic conditions. This study explored the effect of six stilbenoids (batatasin III, oxyresveratrol, piceatannol, pinostilbene, resveratrol, thunalbene) on the gut microbiota composition. Stilbenoids were anaerobically fermented with fecal bacteria from four donors, samples were collected at 0 and 24 h, and effects on the microbiota were assessed by 16S rRNA gene sequencing. Statistical tests identified affected microbes at three taxonomic levels. Observed microbial composition modulation by stilbenoids included a decrease in the Firmicutes to Bacteroidetes ratio, a decrease in the relative abundance of strains from the genus Clostridium, and effects on the family Lachnospiraceae. A frequently observed effect was a further decrease of the relative abundance when compared to the control. An opposite effect to the control was observed for Faecalibacterium prausnitzii, whose relative abundance increased. Observed effects were more frequently attributed to resveratrol and piceatannol, followed by thunalbene and batatasin III. View Full-Text
Keywords: phenolics; polyphenols; stilbenoids; human gut microbiota; 16S rRNA gene sequencing; batatasin III; oxyresveratrol; piceatannol; pinostilbene; resveratrol; thunalbene; fermentation; human colon model; Lachnospiraceae; Firmicutes; Bacteroidetes; Clostridium; Faecalibacterium prausnitzii phenolics; polyphenols; stilbenoids; human gut microbiota; 16S rRNA gene sequencing; batatasin III; oxyresveratrol; piceatannol; pinostilbene; resveratrol; thunalbene; fermentation; human colon model; Lachnospiraceae; Firmicutes; Bacteroidetes; Clostridium; Faecalibacterium prausnitzii
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Jaimes, J.D.; Jarosova, V.; Vesely, O.; Mekadim, C.; Mrazek, J.; Marsik, P.; Killer, J.; Smejkal, K.; Kloucek, P.; Havlik, J. Effect of Selected Stilbenoids on Human Fecal Microbiota. Molecules 2019, 24, 744.

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