Special Issue "NMR-Based Metabolomics"
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 27472
Interests: NMR spectroscopy; organic chemistry; analytical chemistry; metabolomics; NMR-based metabolomics; metabolites; estructural elucidation; molecule identification; LC-MS; chromatography; chirality; enantiomers; enantiodifferentiation; stereochemistry
Interests: molecular phenotyping; analytical chemistry; toxicology; NMR spectroscopy
Small-molecule metabolites are involved in myriad biological processes, and their measurement in appropriately collected samples can provide an efficient route to rich biological insight. Metabolic phenotypes are influenced by a variety of internal (e.g., genetic and epigenetic variation) and external (e.g., environmental exposures, diet, pharmaceutical intervention) factors, and therefore quantitative analysis coupled with appropriate chemometric tools can uncover previously unknown biological relationships and deepen mechanistic understanding.
Techniques for the exploration of metabolic phenotypes have advanced significantly over the past decade. Technological improvements and protocol harmonization/standardization in the metabolomic workflow (experimental design, sample collection and handling, sensitivity and specificity of analysis, and chemometrics) have all contributed to the enhanced utility and applicability of metabolite analysis platforms.
Nuclear magnetic resonance (NMR) spectroscopy is one of the most commonly used metabolomics platforms, providing unique structural information, high dynamic range, and quantitative performance, alongside excellent reproducibility and requiring minimal sample preparation. The ability to characterize intact biofluid and tissue samples remains central to its utility in multiple areas of basic research and clinical studies, and consequently it is an attractive platform for many metabolomic studies.
This Special Issue aims to highlight recent advances in all aspects of NMR-based metabolomics methodology, including NMR pulse sequence development, data processing, and analysis, as well as domain-specific applications such as early disease diagnosis, drug target identiﬁcation, pharmacology, toxicology, environmental studies, plant chemistry, and food and nutrition. Submissions of original research articles, short communications, perspectives, and comprehensive review articles are all welcome.
Dr. Míriam Pérez Trujillo
Dr. Toby Athersuch
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- NMR spectroscopy
- metabolic profiling
- metabolic phenotyping
- personalized healthcare
- molecular epidemiology