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Special Issue "Flow Chemistry in Organic Synthesis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 15 April 2019

Special Issue Editors

Guest Editor
Prof. Dr. Maurizio Benaglia

Dipartimento di Chimica, Università degli Studi di Milano via Golgi 19, 20133 Milano, Italy
Website 1 | Website 2 | E-Mail
Interests: stereoselective synthesis; sustainable methodologies and their application to the synthesis of chiral products of pharmaceutical interest; design and development of chiral organocatalysts; stereoselective reactions in water and other alternative reaction mediums; supported-catalysts and catalytic reactors; enantioselective transformations under continuous-flow conditions; 3D-printing technologies for micro- and mesoreactors
Guest Editor
Prof. Miquel A. Pericàs

Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Tarragona, Spain
Website | E-Mail
Phone: +34 977920243
Interests: asymmetric catalysis; immobilized catalysts; flow chemistry; ligand and catalyst design; photocatalysis; click chemistry; magnetic nanoparticles

Special Issue Information

Dear Colleagues,

In the last years, organic synthesis has been greatly influenced by the widespread diffusion of continuous flow technologies, which have revolutionized not only the synthesis and manufacturing of chemical products but also the design and development of novel reactions.

The present Special Issue Flow Chemistry in Organic Synthesisaims to collect and disseminate some of the most significant and recent contributions in the very wide and highly interdisciplinary area of continuous flow organic reactions.

The scope is broad and includes, among others, the use of micro- and mesofludic devices, flow and catalytic reactors, the application of innovative heating techniques, 3D-printing, photochemical reactions under continuous flow conditions, catalytic and enzymatic transformations, and the development of in-flow reactions in alternative solvents (ionic liquids and deep eutectic solvents). A special focus will be given to the synthesis of chiral molecules, building blocks, or intermediates for the preparation of industrial products, active pharmaceutical ingredients, and biologically active compounds.

Prof. Dr. Maurizio Benaglia
Prof. Miquel A. Pericàs
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Flow reactors
  • Catalytic reactors
  • 3D-printing
  • Enzymatic reactions
  • Deep eutectic solvents
  • Photochemistry
  • Microreactors

Published Papers (1 paper)

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Open AccessArticle Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions
Molecules 2019, 24(4), 726; https://doi.org/10.3390/molecules24040726
Received: 16 January 2019 / Revised: 8 February 2019 / Accepted: 14 February 2019 / Published: 18 February 2019
PDF Full-text (2455 KB) | HTML Full-text | XML Full-text | Supplementary Files
Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of [...] Read more.
Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF3 substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF3 species. We also implemented an in-flow protocol to improve the safety features of the process. Full article
(This article belongs to the Special Issue Flow Chemistry in Organic Synthesis)

Graphical abstract

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Anionic Polymerization using Flow Microreactors
Article Type: Review
Author: Aiichiro Nagaki 

Title: Continuous flow synthesis of the anti-depressant bupropion
Author: Darren Riley

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