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Molecules 2019, 24(4), 726; https://doi.org/10.3390/molecules24040726

Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions

1
Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy
2
Dipartimento di Scienza e Alta Tecnologia, Università degli Studi Dell’Insubria, Via Valleggio 11, 22100 Como, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Maurizio Benaglia
Received: 16 January 2019 / Revised: 8 February 2019 / Accepted: 14 February 2019 / Published: 18 February 2019
(This article belongs to the Special Issue Flow Chemistry in Organic Synthesis)
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Abstract

Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF3 substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF3 species. We also implemented an in-flow protocol to improve the safety features of the process. View Full-Text
Keywords: trifluoromethylselenolation; carbonyl compounds; selenium; fluorinated derivatives; flow chemistry trifluoromethylselenolation; carbonyl compounds; selenium; fluorinated derivatives; flow chemistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Massolo, E.; Pirola, M.; Rossi, S.; Benincori, T. Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions. Molecules 2019, 24, 726.

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