Advances in Enantioselective Syntheses and Chiral Separations

Dear Colleagues,

For many years, the major factor stimulating the search for optically active compounds was the interest in static and dynamic stereochemistry of organic derivatives with various elements of stereogenity, commonly used as models in mechanistic studies. The search for new enantioselective syntheses and enantioselective separation procedures has been stimulated by the rapid development of medicinal chemistry and biochemistry and, in particular, the needs of the pharmaceutical industry, which is now obliged to study very deeply the biological activity of enantiomeric forms of all chiral drugs before their introduction to the market. This Special Issue will provide a contemporary overview of progress on these two topics. From fundamental aspects to applications, any works related to the generation of new stereogenic units based on chemical and chemoenzymatic methodology are thus welcome. In many cases, when enantioselective synthesis cannot be used to obtain optically active derivatives, chiral separation on a preparative scale remains the method of choice. In addition, analytical chiral separation plays a very important role as a tool that allows very fast and accurate determination of enantiomeric excesses of optically active products isolated by various enantioselective procedures and optically active substances isolated from natural sources. Therefore, all contributions dealing with the analytical aspects of chiral separation are also warmly welcome.

Prof. Józef Drabowicz
Guest Editor

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