Special Issue "Directed Drug Design and Molecular Therapy"
Deadline for manuscript submissions: 1 August 2019
Prof. Dr. Mahesh Narayan
The field of drug discovery is experiencing a renaissance. It was not long ago that the pharmaceutical giants reported a gloomy outlook, with no new therapeutics coming into the market. Pharma lines had dried with the soils of tropics having being mined bare for some time. The ocean floor represented an avenue, but it was not easy to harvest. However, the overcast forecast propelled the biomedical community to dig deep and looks for alternative avenues to keep the hits coming. Particularly noteworthy in this light were (and continue to be) the efforts to gain traction into better understanding ligand:receptor interactions using in silico approaches. A second avenue is the development of mechanisms to elucidate the dynamics of receptors and the folding forces that are key to their integrity. A third is the use of unnatural atoms in receptors to unravel their biology. A case in point is the extensive use of Selenium atoms in place of cytseine sulfurs to clarify the functional roles of proteins in complex environments. Such steps are pivotal in directed drug design and improve the odds of a successful outcome (hit), rather than the alternative approach of simply screening millions of compounds. Finally, a fourth approach that has emerged on the horizon is that of tailored therapies. This mechanism takes into account the single nucleotide polymorphisms (SNPs) in individuals that compromise therapeutic outcomes. By examining enzymes such as the cytochrome P450 family for polymorphisms and by also profiling the metabolic products of drug candidates as a function of the SNP, a better therapeutic regimen can be designed.
In sum and substance, clearly the ability to resolve, at a molecular level, the chemistry between a biological host and its ligand guest is key towards bettering the biomedical prospects of disease intervention.
Prof. Mahesh Narayan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- in silico drug-design
- drug-receptor interaction
- molecular dynamics
- single nucleotide polymorphisms