Adenosine Receptors

Dear Colleagues,

Adenosine is a well-known neuromodulator in the central nervous system and has effects on other tissues like immune or circulatory systems. Its physiological actions are exerted through G protein-coupled adenosine receptors (AR), which, in turn, are expressed in a large variety of cells. Interestingly, selective agonists and antagonists for all four AR subtypes have been developed and its diagnostic and therapeutic utility is being pursued.

Using AR as a paradigm of purinergic GPCRs, in this Special Issue, we intended to provide the reader with the recent developments in AR ligands. Thus, the submissions of papers describing new molecules showing activity through AR are welcome. In addition, manuscripts describing new AR-based chemical tools or approaches for the study of adenosine function, prospective analysis for the therapeutic future of AR ligands, and reviews will be also taken into consideration. Finally, authors are encouraged to propose topics that will be evaluated accordingly. Overall, we hope that this timely focused issue summarizing our current knowledge on adenosine receptors ligands will be of interest to a wide range of readers of the journal.

Prof. Dr. Francisco Ciruela
Guest Editor

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