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Molecules 2017, 22(6), 917;

Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases

Department of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, USA
Department of Integrative Medical Sciences, Northeast Ohio Medical University College of Medicine, Rootstown, OH 44272, USA
Author to whom correspondence should be addressed.
Academic Editor: Francisco Ciruela
Received: 16 March 2017 / Revised: 8 May 2017 / Accepted: 25 May 2017 / Published: 1 June 2017
(This article belongs to the Special Issue Adenosine Receptors)
Full-Text   |   PDF [3740 KB, uploaded 1 June 2017]   |  


Cardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine receptors have been connected to several biological pathways affecting the physiology and pathology of the cardiovascular system. In this review, we will cover the different adenosine receptor ligands that have been identified to interact with adenosine receptors and affect the vascular system. These ligands will be evaluated from clinical as well as medicinal chemistry perspectives with more emphasis on how structural changes in structure translate into ligand potency and efficacy. Adenosine receptors represent a novel therapeutic target for development of treatment options treating a wide variety of diseases, including vascular disease and obesity. View Full-Text
Keywords: atherosclerosis; myocardial infarction; cardiac death; vascular tone atherosclerosis; myocardial infarction; cardiac death; vascular tone

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Geldenhuys, W.J.; Hanif, A.; Yun, J.; Nayeem, M.A. Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases. Molecules 2017, 22, 917.

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