Synthesis, Stereochemistry and Applications of Axially Chiral Organic Molecules

Dear Colleagues,

In recent years, compounds containing a stereogenic axis as an element of chirality have received a huge amount of attention due to their important role as catalysts or ligands for asymmetric synthesis and biological active compounds, the latter mainly obtained from natural sources. Using both metal and organocatalytic methodologies, enormous progress has been achieved in their enantioselective synthesis. In particular, the development of innovative reactions, which could give easy access to structurally diverse axially chiral compounds, has produced an unprecedented number of unique classes of axially enantioenriched backbones. The broad applicability of axially chiral compounds, not only in the abovementioned fields, but also in the material and pharmacological sciences, make their synthesis a continuous and fascinating challenge for the chemist community.

This Special Issue will focus on recent developments in the synthesis, application, as well as characterization of novel structures of compounds falling into the definition of axially chiral compounds, such as atropisomers, allenes, alkylidenes, spiranes, and so on.

Prof. Giorgio Bencivenni
Guest Editor

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