molecules-logo

Journal Browser

Journal Browser

Special Issue "Bioactive Compounds in Plant Extracts: Anti-inflammatory, Antioxidant, and Anticancer Properties and Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 20 November 2023 | Viewed by 878

Special Issue Editors

National Institute of Complementary Medicine (NICM), Western Sydney University, Penrith, NSW 2751, Australia
Interests: anti-inflammatory; antioxidant; anticancer; bioactive compounds; plant extracts; pharmacology
Special Issues, Collections and Topics in MDPI journals
Centre of Molecular and Environmental Biology (CBMA), Department of Biology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Interests: natural compounds; bioactivities; anti-inflammatory; antioxidants
Special Issues, Collections and Topics in MDPI journals
Dr. Saiwang Seto
E-Mail Website
Guest Editor
1. Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong, China
2. Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, China
Interests: vascular biology; inflammation; pharmacology; natural products

Special Issue Information

Dear Colleagues,

There is increasing interest in plant-derived bioactive compounds. These compounds are not only involved in the actions of various plant extracts which have long been used in traditional and complementary medicines, but also as sources of lead compounds for developing new drugs or therapeutics for treating various diseases and conditions such as cancer, cardiovascular and neurodegenerative diseases, diabetes, pain, and chronic inflammation. Many of these compounds, such as polyphenols, have been widely studied.

This Special Issue focusses on the antioxidant, anti-inflammatory, and anti-cancer properties of plant-derived bioactive compounds and their roles in the prevention and treatment of related diseases and conditions. It includes original research papers and reviews and covers all aspects of the topic, ranging from chemical analysis, synthesis, pharmacology, and toxicology to mechanism of actions including potential molecular targets and signaling pathways, as well as clinical applications.

Prof. Dr. Chun Guang Li
Prof. Dr. Alberto C. P. Dias
Dr. Saiwang Seto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-inflammatory
  • antioxidant
  • anticancer
  • bioactive compounds
  • plant extracts
  • properties
  • bioactivity
  • drug targets
  • application

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
The Cytotoxic Activity of Dammarane-Type Triterpenoids Isolated from the Stem Bark of Aglaia cucullata (Meliaceae)
Molecules 2023, 28(13), 4946; https://doi.org/10.3390/molecules28134946 - 23 Jun 2023
Viewed by 532
Abstract
The Aglaia genus, a member of the Meliaceae family, is generally recognized to include a number of secondary metabolite compounds with diverse structures and biological activities, including triterpenoids. Among the members of this genus, Aglaia cucullata has been reported to have unique properties [...] Read more.
The Aglaia genus, a member of the Meliaceae family, is generally recognized to include a number of secondary metabolite compounds with diverse structures and biological activities, including triterpenoids. Among the members of this genus, Aglaia cucullata has been reported to have unique properties and thrives exclusively in mangrove ecosystems. This plant is also known to contain various metabolites, such as flavaglines, bisamides, and diterpenoids, but there are limited reports on the isolation of triterpenoid compounds from its stem bark. Therefore, this research attempted to isolate and elucidate seven triterpenoids belonging to dammarane-type (17) from the stem bark of Aglaia cucullata. The isolated compounds included 20S,24S-epoxy-3α,25-dihydroxy-dammarane (1), dammaradienone (2), 20S-hydroxy-dammar-24-en-3-on (3), eichlerianic acid (4), (20S,24RS)-23,24-epoxy-24-methoxy-25,26,27-tris-nor dammar-3-one (5), 3α-acetyl-cabraleahydroxy lactone (6), and 3α-acetyl-20S,24S-epoxy-3α,25-dihydroxydammarane (7). Employing spectroscopic techniques, the chemical structures of the triterpenoids were identified using FTIR, NMR, and HRESITOF-MS. The cytotoxic activity of compounds 17 was tested with the PrestoBlue cell viability reagent against MCF-7 breast cancer, B16-F10 melanoma, and CV-1 normal kidney fibroblast cell lines. The results displayed that compound 5 had the highest level of bioactivity compared to the others. Furthermore, the IC50 values obtained were more than 100 μM, indicating the low potential of natural dammarane-type triterpenoids as anticancer agents. These findings provided opportunities for further studies aiming to increase their cytotoxic activities through semi-synthetic methods. Full article
Show Figures

Graphical abstract

Back to TopTop