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Molecules
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Nutraceuticals in Nanomedicine Applications
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Nutraceuticals in Nanomedicine Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 16679

Special Issue Editors

Prof. Dr. Tamer Elbayoumi

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences & Nanomedicine Center of Excellence (COE), College of Pharmacy-Glendale, Midwestern University, Glendale, AZ, USA
Interests: nanomedicine; nutraceuticals; targeted delivery of therapeutics and contrasts; pharmaceutical formulations; cancer and cardiovascular pharmacotherapies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Imran Saleem

E-Mail Website
Guest Editor
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
Interests: nanomedicine; nanoparticle toxicology; nanocarriers for pulmonary/nasal delivery (small molecules and macromolecules/vaccines); smart responsive nanocarriers
Special Issues, Collections and Topics in MDPI journals
Dr. Satyanarayana Somavarapu

E-Mail Website
Guest Editor
Department of Pharmaceutics, University College London (UCL) School of Pharmacy, London WC1N 1AX, UK
Interests: nanotechnology for the local and systemic delivery of phytochemicals; hybrid nano-carriers for mucosal; ocular and pulmonary delivery of therapeutics

Special Issue Information

Dear Colleagues,

Nutraceuticals (defined as components/nutrients isolated or purified from foods, which have medical or health benefits besides providing nutrition) have gained increased prominence in clinical applications. Nutraceuticals not only offer protection against numerous pathologies, including cardiovascular diseases, cancer, diabetes, arthritis, immunological, inflammatory, and neurodegenerative disorders, but are also used in the treatment of these conditions. The applications of nanotechnology in nutraceuticals are rapidly growing, with the main aim of enhancing their biological activities. The success of nutraceutical nanomedicines is attributed to the ability of nanocarrier technologies to improve the solubility, stability, and systemic bioavailability of the encapsulated active phytochemical ingredient(s). Moreover, novel nanocarrier systems can provide site-specific delivery of nutraceutical cargo, in addition to its controlled/sustained release from the nano-formulation, thus enhancing the overall therapeutic efficacy.

The main aim of this Special Issue on "Nutraceuticals in Nanomedicine Applications" is to serve as an open forum where researchers may share their current findings, evaluations, and expert opinions in this ever-growing area of nutraceutical nanomedicines. Thanks to the current nanomedical evolution, the scope of this scientific development area has expanded to include novel hybrid (organic and in-organic/metalloid) nanoplatforms and nanocomposites, with varying nutraceutical cargos, such as semi-synthetic molecules, compounds, and conjugates, in addition to the traditional isolated or purified components. The broad focus of this issue will include not only parenteral, topical, and oral routes of administration, but also mucosal and ocular delivery, as well as combination/coated medical devices, implants, and even wearables, which can be used for drug delivery and probing/sensing/diagnostic applications too.

Here, we invite both original research and review articles on all aspects of nutraceutical nanotechnology product development, to help increase their visibility and enhance the clinical prospects along with industrial applications of these advanced systems.

Prof. Dr. Tamer Elbayoumi
Prof. Dr. Imran Saleem
Dr. Satyanarayana Somavarapu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutraceuticals
  • supplements
  • bioactive compounds/analogues
  • semi-synthetic molecules, compounds, and conjugates
  • disease prevention and treatment
  • nanoformulations
  • hybrid nanoplatforms/nanosystems
  • combination/coated medical devices
  • probing/sensing/diagnostic applications
  • physico-chemical characterization
  • bioavailability
  • pharmacodynamics
  • localized/systemic administration
  • targeted delivery
  • safety and efficacy

Published Papers (3 papers)

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Research

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10 pages, 2784 KiB  
Article
Nanoformulated Ajwa (Phoenix Dactylifera) Bioactive Compounds Improve the Safety of Doxorubicin without Compromising Its Anticancer Efficacy in Breast Cancer
by Kavitha Godugu, Ali H. El-Far, Soad Al Jaouni and Shaker A. Mousa
Molecules 2020, 25(11), 2597; https://doi.org/10.3390/molecules25112597 - 03 Jun 2020
Cited by 11 | Viewed by 2751 | Correction
Abstract
One of the major causes of women’s death in the world is breast cancer. Consequently, numerous regimens for the control of this severe disease have been created. The chemotherapeutic agent doxorubicin (DOX) is frequently used to treat breast cancer, but DOX can also [...] Read more.
One of the major causes of women’s death in the world is breast cancer. Consequently, numerous regimens for the control of this severe disease have been created. The chemotherapeutic agent doxorubicin (DOX) is frequently used to treat breast cancer, but DOX can also cause cardiotoxic effects that lead to heart failure. Therefore, many research studies have been done to find a natural product that effectively potentiates or does not interfere with DOX’s anticancer effect and protects against its cardiotoxicity. We studied the impact of combined nanoformulated Ajwa (Phoenix dactylifera) selected bioactive compounds (BAC) rutin (R) and quercetin (Q) in nude mice breast cancer xenografts on DOX-mediated anticancer efficacy. We also studied if this Ajwa BAC could safeguard against DOX-mediated cardiomyopathies by evaluating plasma cardiac troponin-I (cTn-I) levels and cardiac histopathology. Nanoformulated Ajwa BAC effectively alleviated weight loss induced by DOX in mice and significantly decreased the elevated cTn-I. Furthermore, 5 mg RQ-NPs/kg of nude mice that subcutaneously daily injected for 11 days, attenuated the histopathological alterations induced in cardiac muscles due to DOX without any interference with the anticancer effects of DOX against breast cancer. Full article
(This article belongs to the Special Issue Nutraceuticals in Nanomedicine Applications)
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11 pages, 6224 KiB  
Article
Resveratrol and Its Nanoformulation Attenuate Growth and the Angiogenesis of Xenograft and Orthotopic Colon Cancer Models
by Thangirala Sudha, Ali H. El-Far, Deena S. Mousa and Shaker A. Mousa
Molecules 2020, 25(6), 1412; https://doi.org/10.3390/molecules25061412 - 20 Mar 2020
Cited by 27 | Viewed by 3537
Abstract
Cancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type is the third most common cancer globally. Resveratrol (RSV) is a natural compound with an effective anticancer effect, especially against colorectal cancer, and therefore numerous studies recommended its use in [...] Read more.
Cancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type is the third most common cancer globally. Resveratrol (RSV) is a natural compound with an effective anticancer effect, especially against colorectal cancer, and therefore numerous studies recommended its use in colorectal cancer prevention and treatment. The current study investigated the effect of either RSV or its nanoformulation (NP-RSV) on the growth and vascularity of xenograft and orthotopic mice models in colon cancer (COLO205-luc). Both RSV and NP-RSV induced significant reductions in tumor growth and the hemoglobin percentages of the tumor mass, but NP-RSV showed greater bioavailability and efficacy than RSV. Generally, we recommend using NP-RSV as a therapeutic to control colon cancer. Full article
(This article belongs to the Special Issue Nutraceuticals in Nanomedicine Applications)
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Review

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25 pages, 1882 KiB  
Review
Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability
by Bingjing Zheng and David Julian McClements
Molecules 2020, 25(12), 2791; https://doi.org/10.3390/molecules25122791 - 17 Jun 2020
Cited by 134 | Viewed by 9576
Abstract
Curcumin is a bioactive constituent isolated from turmeric that has historically been used as a seasoning, pigment, and herbal medicine in food. Recently, it has become one of the most commonly studied nutraceuticals in the pharmaceutical, supplement, and food areas because of its [...] Read more.
Curcumin is a bioactive constituent isolated from turmeric that has historically been used as a seasoning, pigment, and herbal medicine in food. Recently, it has become one of the most commonly studied nutraceuticals in the pharmaceutical, supplement, and food areas because of its myriad of potential health benefits. For instance, it is claimed to exhibit antioxidant, anti-inflammatory, antimicrobial, antiparasite, and anticancer activities when ingested as a drug, supplement, or food. Toxicity studies suggest that it is safe to consume, even at relatively high levels. Its broad-spectrum biological activities and low toxicity have meant that it has been widely explored as a nutraceutical ingredient for application in functional foods. However, there are several hurdles that formulators must overcome when incorporating curcumin into commercial products, such as its low water solubility (especially under acidic and neutral conditions), chemical instability (especially under neutral and alkaline conditions), rapid metabolism by enzymes in the human body, and limited bioavailability. As a result, only a small fraction of ingested curcumin is actually absorbed into the bloodstream. These hurdles can be at least partially overcome by using encapsulation technologies, which involve trapping the curcumin within small particles. Some of the most commonly used edible microparticles or nanoparticles utilized for this purpose are micelles, liposomes, emulsions, solid lipid particles, and biopolymer particles. Each of these encapsulation technologies has its own benefits and limitations for particular product applications and it is important to select the most appropriate one. Full article
(This article belongs to the Special Issue Nutraceuticals in Nanomedicine Applications)
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