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Theme Issue Honoring Professor Philippe Jeandet’s 60th Birthday: Bioactivity and Chemical Diversity of Natural Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 12510

Special Issue Editors


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Guest Editor
1. Department of Pharmacy, Southeast University, Dhaka, Bangladesh
2. Pharmakon Neuroscience Research Network, Dhaka, Bangladesh
Interests: neuropharmacology; pharmacognosy; medicinal chemistry; neurochemistry; dementia

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Guest Editor
1. Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
2. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Interests: natural products; medicine; neurology; dementia; proteomics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
National Centre for Scientific Research (CNRS 6249), Université de Franche-Comté, F-25030 Besançon, France
Interests: medicine; public health; environmental health/ecology; one health; pharmacy; pharmacology; sustainability; medicine; clinical trials; experimental studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In 2020, Dr. Philippe Jeandet, Professor of Food Chemistry at the Faculty of Sciences of the University of Reims, has his 60th birthday. In recognition of his outstanding lifetime scientific contribution, we have arranged a Special Issue to which you are invited to submit a manuscript.

Prof. Dr. Philippe Jeandet is born on 18 April, 1960, in Beaune, France, in the heart of the Burgundy wine-growing area. He studied biological sciences and specialized in plant sciences as well as in organic chemistry at the Faculty of Sciences of the University of Bourgogne. He earned his PhD degree in plant physiology and biochemistry in 1991 and 1996, respectively, from the same university. He started his research activities on natural products, namely, resveratrol, a phytoalexin from the Vitaceae. His PhD thesis was the first to be defended in a French University on resveratrol. His work was supervised by Prof. Dr. Roger Bessis. He received an Associate Professor position at the University of Bourgogne in 1993. Philippe Jeandet spent several months as a Visiting Scientist at the Federal Agronomic Station of Changins, Switzerland, in 1994 and as a Visiting Professor at the University of Kentucky, USA, in 1997. He was then appointed in 1997 as a Full Professor of Food Chemistry and Chairman of the Laboratory of Oenology and Applied Chemistry at the University of Reims (1997-2013). During this period, his research activities focused on the role of macromolecules on the physico-chemistry of wine, the wine proteome as well as on wine microbiology, while continuing some research activities on resveratrol and related stilbenes. He has been the Director (2003-2007) and Deputy Director (2008-2012) of the research unit “Vine and Wine of Champagne” and Adjunct to the Director of Research and Technology (2004-2010) in the Champagne-Ardennes area (French ministry of research). Today, Philippe Jeandet has joined the research unit “Induced Resistance and Plant Bioprotection”. He has resumed his research activities on natural products and applications with a particular interest in the chemistry and bioactivity of stilbenes. He has published over 300 papers in scholarly journals, edited three books, and edited or co-edited seven special issues. Philippe Jeandet has also presented more than 260 Communications to numerous symposia and congresses. He is/has been member of the editorial board of several journals such as American Journal of Enology and Viticulture, Journal of Agricultural and Food Chemistry, Journal of Chemistry, International Journal of Wine Research, Plant Science Today, International Journal of Food Fermentation Technology, and Frontiers in Pharmacology and Molecules. In 2019, he joined the Pharmakon Neuroscience Research Network. According to Google Scholar data, Philippe Jeandet has over 10,000 citations and an h-index of 50.

Natural compounds produced by living organisms are the backbone of modern medicine. The therapeutic potential of natural products is as old as human civilization and used to treat several acute and chronic diseases. These compounds have diverse pharmacological activity and heterogeneous chemical structures that may lead to the commercial development of lead compounds.  A number of currently used Food and Drug Administration-approved drugs are derived from natural compounds. Furthermore, many synthetic and semisynthetic drug candidates with improved potency and safety are also inspired by natural compounds. The complexity and molecular diversity of natural products continue to offer novel lead compounds against countless pharmacological targets including cancer, atherosclerosis, diabetes, hypertension, malaria, cardiac diseases, and neurological disorders. Structural diversity is not only the unique feature of natural products that inspire drug discovery and development. Additionally, these compounds based on the study of their mechanisms of action often exert high receptor-binding and specific biological activity.

In this Special Issue, we welcome experts to contribute their original articles exploring the biological activity and structural diversity of chemical entities derived from mother nature. Review articles, particularly those dealing with the themes mentioned above, are also welcome.

Mr. Md. Sahab Uddin
Dr. Ghulam Md Ashraf
Prof. Dr. Lotfi Aleya
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Acute disease
  • Biological activity and mechanisms of action
  • Bioavailability
  • Chemical synthesis including whole-cell biocatalytic, enzymatic and green chemistry methods for their production
  • Chronic disease
  • Drug development
  • Drug discovery
  • Natural compounds
  • Natural products
  • Neurological diseases
  • Structure elucidation
  • Structure-activity relationship

Published Papers (4 papers)

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Research

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20 pages, 4777 KiB  
Article
Neuroprotective Ability of Apocynin Loaded Nanoparticles (APO-NPs) as NADPH Oxidase (NOX)-Mediated ROS Modulator for Hydrogen Peroxide-Induced Oxidative Neuronal Injuries
by Manisha Singh, Shriya Agarwal, Raj Kumar Tiwari, Silpi Chanda, Kuldeep Singh, Prakhar Agarwal, Aishwarya Kashyap, Pranav Pancham, Shweta Mall, Rachana R. and Shalini Sharma
Molecules 2021, 26(16), 5011; https://doi.org/10.3390/molecules26165011 - 18 Aug 2021
Cited by 4 | Viewed by 2535
Abstract
Apocynin (APO) is a known multi-enzymatic complexed compound, employed as a viable NADPH oxidase (NOX) inhibitor, extensively used in both traditional and modern-day therapeutic strategies to combat neuronal disorders. However, its therapeutic efficacy is limited by lower solubility and lesser bioavailability; thus, a [...] Read more.
Apocynin (APO) is a known multi-enzymatic complexed compound, employed as a viable NADPH oxidase (NOX) inhibitor, extensively used in both traditional and modern-day therapeutic strategies to combat neuronal disorders. However, its therapeutic efficacy is limited by lower solubility and lesser bioavailability; thus, a suitable nanocarrier system to overcome such limitations is needed. The present study is designed to fabricate APO-loaded polymeric nanoparticles (APO-NPs) to enhance its therapeutic efficacy and sustainability in the biological system. The optimized APO NPs in the study exhibited 103.6 ± 6.8 nm and −13.7 ± 0.43 mV of particle size and zeta potential, respectively, along with further confirmation by TEM. In addition, the antioxidant (AO) abilities quantified by DPPH and nitric oxide scavenging assays exhibited comparatively higher AO potential of APO-NPs than APO alone. An in-vitro release profile displayed a linear diffusion pattern of zero order kinetics for APO from the NPs, followed by its cytotoxicity evaluation on the PC12 cell line, which revealed minimal toxicity with higher cell viability, even after treatment with a stress inducer (H2O2). The stability of APO-NPs after six months showed minimal AO decline in comparison to APO only, indicating that the designed nano-formulation enhanced therapeutic efficacy for modulating NOX-mediated ROS generation. Full article
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18 pages, 2489 KiB  
Article
VOCs Are Relevant Biomarkers of Elicitor-Induced Defences in Grapevine
by Christelle Lemaitre-Guillier, Christelle Dufresne, Agnès Chartier, Stéphanie Cluzet, Josep Valls, Lucile Jacquens, Antonin Douillet, Nicolas Aveline, Marielle Adrian and Xavier Daire
Molecules 2021, 26(14), 4258; https://doi.org/10.3390/molecules26144258 - 13 Jul 2021
Cited by 11 | Viewed by 3156
Abstract
Grapevine is susceptible to fungal diseases generally controlled by numerous chemical fungicides. Elicitors of plant defence are a way of reducing the use of these chemicals, but still provide inconsistent efficiency. Easy-to-analyse markers of grapevine responses to elicitors are needed to determine the [...] Read more.
Grapevine is susceptible to fungal diseases generally controlled by numerous chemical fungicides. Elicitors of plant defence are a way of reducing the use of these chemicals, but still provide inconsistent efficiency. Easy-to-analyse markers of grapevine responses to elicitors are needed to determine the best conditions for their efficiency and position them in protection strategies. We previously reported that the elicitor sulphated laminarin induced the emission of volatile organic compounds (VOCs) by grapevine leaves. The present study was conducted to characterise and compare VOC emissions in response to other elicitors. Bastid® was first used to test the conditions of VOC collection and analysis. Using SBSE-GC-MS, we detected several VOCs, including the sesquiterpene α-farnesene, in a time-dependent manner. This was correlated with the induction of farnesene synthase gene expression, in parallel with stilbene synthesis (another defence response), and associated to resistance against downy mildew. The other elicitors (Redeli®, Romeo®, Bion®, chitosan, and an oligogalacturonide) induced VOC emission, but with qualitative and quantitative differences. VOC emission thus constitutes a response of grapevine to elicitors of various chemical structures. Therefore, VOC analysis is relevant for studying the impact of environmental factors on grapevine defence responses and optimising the performance of elicitors in vineyards. Full article
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13 pages, 2526 KiB  
Article
Mitigating Effect of Lindera obtusiloba Blume Extract on Neuroinflammation in Microglial Cells and Scopolamine-Induced Amnesia in Mice
by Song-Hee Jo, Tae-Bong Kang, Sushruta Koppula, Duk-Yeon Cho, Joon-Soo Kim, In-Su Kim and Dong-Kug Choi
Molecules 2021, 26(10), 2870; https://doi.org/10.3390/molecules26102870 - 12 May 2021
Cited by 5 | Viewed by 2181
Abstract
Lindera obtusiloba Blume (family, Lauraceae), native to Northeast Asia, has been used traditionally in the treatment of trauma and neuralgia. In this study, we investigated the neuroinflammatory effect of methanol extract of L. obtusiloba stem (LOS-ME) in a scopolamine-induced amnesia model and lipopolysaccharide [...] Read more.
Lindera obtusiloba Blume (family, Lauraceae), native to Northeast Asia, has been used traditionally in the treatment of trauma and neuralgia. In this study, we investigated the neuroinflammatory effect of methanol extract of L. obtusiloba stem (LOS-ME) in a scopolamine-induced amnesia model and lipopolysaccharide (LPS)-stimulated BV2 microglia cells. LOS-ME downregulated the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, inflammatory cytokines, and inhibited the phosphorylation of nuclear factor kappa-B (NF-ĸB) and extracellular signal-regulated kinase (ERK) in LPS-stimulated BV2 cells. Male C57/BL6 mice were orally administered 20 and 200 mg/kg of LOS-ME for one week, and 2 mg/kg of scopolamine was administered intraperitoneally on the 8th day. In vivo behavioral experiments (Y-maze and Morris water maze test) confirmed that LOS-ME alleviated cognitive impairments induced by scopolamine and the amount of iNOS expression decreased in the hippocampus of the mouse brain. Microglial hyper-activation was also reduced by LOS-ME pretreatment. These findings suggest that LOS-ME might have potential in the treatment for cognitive improvement by regulating neuroinflammation. Full article
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Review

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14 pages, 970 KiB  
Review
Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
by Simona Bungau, Cosmin Mihai Vesa, Areha Abid, Tapan Behl, Delia Mirela Tit, Anamaria Lavinia Purza, Bianca Pasca, Laura Maghiar Todan and Laura Endres
Molecules 2021, 26(9), 2407; https://doi.org/10.3390/molecules26092407 - 21 Apr 2021
Cited by 18 | Viewed by 3172
Abstract
Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have [...] Read more.
Withaferin A (WFA) was identified as the most active phytocompound of the plant Withania somnifera (WS) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies. Full article
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