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Computer Modeling of Alzheimer’s Disease—Simulations of Synaptic Plasticity and Memory in the CA3-CA1 Hippocampal Formation Microcircuit

1
Intrafaculty College of Medical Informatics and Biostatistics, Medical University of Gdańsk, 1 Debinki St., 80-211 Gdańsk, Poland
2
Department of Anatomy and Neurobiology, Medical University of Gdańsk, 1 Debinki St., 80-211 Gdańsk, Poland
3
Department of Periodontology and Oral Mucosa Diseases, Medical University of Gdańsk, 1a Debowa St., 80-204 Gdańsk, Poland
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(10), 1909; https://doi.org/10.3390/molecules24101909
Received: 22 April 2019 / Revised: 12 May 2019 / Accepted: 16 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Molecules against Alzheimer II)
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Abstract

This paper aims to present computer modeling of synaptic plasticity and memory in the CA3-CA1 hippocampal formation microcircuit. The computer simulations showed a comparison of a pathological model in which Alzheimer’s disease (AD) was simulated by synaptic degradation in the hippocampus and control model (healthy) of CA3-CA1 networks with modification of weights for the memory. There were statistically higher spike values of both CA1 and CA3 pyramidal cells in the control model than in the pathological model (p = 0.0042 for CA1 and p = 0.0033 for CA3). A similar outcome was achieved for frequency (p = 0.0002 for CA1 and p = 0.0001 for CA3). The entropy of pyramidal cells of the healthy CA3 network seemed to be significantly higher than that of AD (p = 0.0304). We need to study a lot of physiological parameters and their combinations of the CA3-CA1 hippocampal formation microcircuit to understand AD. High statistically correlations were obtained between memory, spikes and synaptic deletion in both CA1 and CA3 cells. View Full-Text
Keywords: Alzheimer’s disease; hippocampus; LTP; theta rhythm; computer simulation Alzheimer’s disease; hippocampus; LTP; theta rhythm; computer simulation
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Świetlik, D.; Białowąs, J.; Moryś, J.; Klejbor, I.; Kusiak, A. Computer Modeling of Alzheimer’s Disease—Simulations of Synaptic Plasticity and Memory in the CA3-CA1 Hippocampal Formation Microcircuit. Molecules 2019, 24, 1909.

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