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Molecules 2018, 23(12), 3230; https://doi.org/10.3390/molecules23123230 (registering DOI)

Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer’s Disease

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
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Author to whom correspondence should be addressed.
Academic Editors: Diego Muñoz-Torrero and Michael Decker
Received: 22 November 2018 / Revised: 4 December 2018 / Accepted: 5 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Molecules against Alzheimer II)
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Abstract

The cholinergic hypothesis has been reported first being the cause of memory dysfunction in the Alzheimer’s disease. Researchers around the globe have focused their attention on understanding the mechanisms of how this complicated system contributes to processes such as learning, memory, disorientation, linguistic problems, and behavioral issues in the indicated chronic neurodegenerative disease. The present review reports recent updates in hybrid molecule design as a strategy for selectively addressing multiple target proteins involved in Alzheimer’s disease (AD) and the study of their therapeutic relevance. The rationale and the design of the bifunctional compounds will be discussed in order to understand their potential as tools to investigate the role of the cholinergic system in AD. View Full-Text
Keywords: AChE inhibitor; Alzheimer’s disease; bitopic ligand; cholinergic system; hybrid molecules; muscarinic receptors; nicotinic receptors AChE inhibitor; Alzheimer’s disease; bitopic ligand; cholinergic system; hybrid molecules; muscarinic receptors; nicotinic receptors
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Volpato, D.; Holzgrabe, U. Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer’s Disease. Molecules 2018, 23, 3230.

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