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Synthesis and Characterization of Heterocycles with Potential Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 690

Special Issue Editor


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Guest Editor
Centro de Química, Universidade do Minho (CQ/UM), Campus de Gualtar, 4710-057 Braga, Portugal
Interests: metal-catalyzed reactions (cross-couplings, C-H activation, and carbonylations); nucleophilic aromatic substitution; synthesis of heterocycles of N and/or S; antitumoral and anti-angiogenic compounds
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Special Issue Information

Dear Colleagues,

The synthesis and characterization of heterocyclic compounds have attracted considerable interest due to their importance in medicinal chemistry, materials science, and catalysis. This Special Issue is focused on the design, synthesis, and comprehensive characterization of various heterocyclic structures. Different synthetic methodologies, including their greener versions, are of interest, alongside structural characterization, usually performed using a combination of techniques such as nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), high-resolution mass spectrometry (HRMS), elemental analysis, and, in some cases, X-ray crystallography. The resulting heterocycles may exhibit promising properties that can be further evaluated for their potential applications in pharmaceuticals, agrochemicals, and materials science. This Special Issue will highlight the synthetic versatility of the heterocyclic compounds prepared, their comprehensive characterization, and their importance in modern chemical research, including their wide range of applications in various industries.

The synthesis and characterization of heterocyclic compounds have attracted considerable interest due to their importance in medicinal chemistry, materials science, and catalysis.

I am pleased to invite you to submit original research articles and reviews focused on the design, versatile synthesis, and comprehensive characterization of various heterocyclic structures, highlighting the importance of heterocycles in modern chemical research, including their wide range of applications in various industries.

Dr. Maria João Queiroz
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heterocycles
  • synthesis
  • design
  • characterization
  • green methods
  • applications

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Published Papers (1 paper)

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Research

18 pages, 1326 KB  
Article
Synthesis, Antiparasitic Activity and Substituent Effects of Methyl 5-(Hetero)aryl or Alicyclicaminothieno[2,3-b]pyridine-2-carboxylates
by Francisco Ribeiro, Juliana P. Sousa, Nuno Santarém, Joana Tavares, Anabela Cordeiro-da-Silva and Maria-João R. P. Queiroz
Molecules 2026, 31(8), 1313; https://doi.org/10.3390/molecules31081313 - 17 Apr 2026
Viewed by 278
Abstract
Di(hetero) aryl and alicyclic amine derivatives of thieno[2,3-b]pyridine were synthesized in good to high yields (45–76%) via palladium-catalyzed Buchwald–Hartwig amination. The reactions were performed using methyl 5-bromothieno[2,3-b]pyridine-2-carboxylate, prepared in this work, and a variety of substituted anilines bearing either [...] Read more.
Di(hetero) aryl and alicyclic amine derivatives of thieno[2,3-b]pyridine were synthesized in good to high yields (45–76%) via palladium-catalyzed Buchwald–Hartwig amination. The reactions were performed using methyl 5-bromothieno[2,3-b]pyridine-2-carboxylate, prepared in this work, and a variety of substituted anilines bearing either electron-donating groups (EDGs) or electron-withdrawing groups (EWGs), as well as pyridinyl amines, and saturated heterocyclic amines such as morpholine and piperidine. For most substrates, the optimal conditions involved Pd(OAc)2, rac-BINAP, and Cs2CO3 in toluene at 100 °C under argon. Substrate bearing EWGs and electron-deficient pyridinyl amines required Xantphos as the ligand, while reactions with piperidine were only successful using Pd2(dba)3 as a palladium (0) source. The antiparasitic activity of the synthesized compounds was evaluated against Trypanosoma brucei (T. brucei) and Leishmania infantum (L. infantum) in both promastigote and amastigote forms. Most compounds exhibited no significant cytotoxicity (CC50 > 100 μM) in PMA-differentiated THP-1 derived macrophage cells. Analysis of substituent effects focusing on the nature of amino substitution at position C(5) revealed distinct trends in antiparasitic activity. Notably, one compound exhibited activity against Leishmania infantum promastigotes that was nearly four times higher than that of the reference drug miltefosine, and its selectivity index was also approximately fourfold higher. Full article
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