Design, Synthesis and Biological Evaluation of Novel Heterocyclic Antitumor Compounds, 2nd Edition

Dear Colleagues,

Heterocyclic compounds, such as monocyclic and fused ring systems, represent the largest and most diverse family of organic compounds with biological active properties, namely antitumor and/or antiangiogenic activities. The ability to bind via hydrogen bonding or hydrophobic interactions seems to be an important factor in the development of target-based molecular designs using docking studies. Pharmacokinetics (absorption, distribution, metabolism, excretion, toxicity, or ADMET) may also be predicted by in silico studies and confirmed afterwards. The synthesis of novel heterocyclic compounds with antitumor and/or antiangiogenic properties using different methodologies, including those that are more sustainable (green), continues to interest many researchers around the world. The evaluation of their antitumor/antiangiogenic properties and toxicity remains essential in the search for compounds with better efficacy and fewer side effects than the ones currently in use to treat different types of cancer. Researchers in the field are cordially invited to submit relevant manuscripts to this Special Issue of Molecules, “Design, Synthesis and Biological Evaluation of Novel Heterocyclic Antitumor Compounds, 2nd Edition”.

Prof. Dr. Maria João Queiroz
Guest Editor

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• heterocycles
• synthetic methodologies including green chemistry
• antitumor evaluation
• structure–activity relationships
• target-based design
• docking studies
• pharmacokinetics (ADMET)

• Design, Synthesis and Biological Evaluation of Novel Heterocyclic Antitumor Compounds in Molecules (5 articles)