Isoxazolines in Medicinal Chemistry and Natural Products

Dear Colleagues,

We cordially invite you to contribute original research papers or reviews to this Special Issue of Molecules entitled “Isoxazolines in Medicinal Chemistry and Natural Products”. Obtained from natural sources or by synthetic routes, Δ2-isoxazolines (4,5-dihydroisoxazoles) are a class of five-membered heterocyclic compounds that have gained much interest in the field of medicinal chemistry due to their wide range of biological properties, including anti-inflammatory, anticancer, antifungal, antibacterial, antituberculosis, antimalarial, cholinergic, and glutamatergic activities, among others. The structural features of isoxazolines make them suitable for multiple non-covalent interactions, especially hydrogen bonds and hydrophobic interactions. The introduction of an isoxazoline ring in synthetic or natural bioactive compounds often results in increased efficacy, decreased toxicity, and improved pharmacokinetics.

This Special Issue aims to provide a broad survey of the most recent advances in this topic. We invite you to submit original research and review articles related to up-to-date and ongoing studies focusing on the design of isoxazoline bioactive compounds, their preparation, and pharmacological evaluation, as well as on the isolation, identification, synthesis, and biological characterization of isoxazoline-containing natural products. Papers that cover new methodologies for the synthesis and functionalization of isoxazolines are also welcome.