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Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent

College of Pharmacy, Dongguk University, Seoul 04620, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Yasuyoshi Miyata
Molecules 2019, 24(20), 3659; https://doi.org/10.3390/molecules24203659
Received: 20 August 2019 / Revised: 29 September 2019 / Accepted: 8 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Anti-Cancer Drug: Discovery, Development and Combination)
Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine. Its effects last for several days after a single oral dose and it can be administered once a week to provide better compliance and symptom control. Recently; strong antitumour effects for penfluridol were discovered in various cancer cell lines; such as breast; pancreatic; glioblastoma; and lung cancer cells via several distinct mechanisms. Therefore; penfluridol has drawn much attention as a potentially novel anti-tumour agent. In addition; the anti-cancer effects of penfluridol have been demonstrated in vivo: results showed slight changes in the volume and weight of organs at doses tested in animals. This paper outlines the potential for penfluridol to be developed as a next-generation anticancer drug. View Full-Text
Keywords: penfluridol; antipsychotic; drug repositioning; hallmarks of cancer; autophagy; glioblastoma penfluridol; antipsychotic; drug repositioning; hallmarks of cancer; autophagy; glioblastoma
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Tuan, N.M.; Lee, C.H. Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent. Molecules 2019, 24, 3659.

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