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Research Progress of Gemini Surfactants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 365

Special Issue Editors


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Guest Editor
Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University Poznan, 61-614 Poznan, Poland
Interests: spectroscopy; organic synthesis; molecular interactions; surface chemistry; microbiocide chemistry; betaines; corrosion inhibition
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Bioactive Compounds, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznan, Poland
Interests: organic synthesis; molecular interactions; surface chemistry; microbiocide chemistry; smart materials; corrosion inhibition; environmental chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Emerging gemini surfactants possess a unique dimeric architecture that confers superior physicochemical and biological properties compared to conventional surfactants. Their versatile hydrophilic–lipophilic balance (HLB) makes them extremely valuable as innovative materials across multiple scientific domains.

In chemistry, they play a significant role in corrosion inhibition, micellar catalysis, nanoparticle synthesis, the preparation of supramolecular solvents and nanoemulsions, the synthesis of precisely defined polymers, and fluid rheology. In pharmacy and medicine, they serve as potent biocides, effective drug carriers, capping agents for metal nanoparticles with biocidal properties, and promising nonviral gene delivery systems. In optoelectronics, they enable the formation of spatial networks of well-dispersed molecules for advanced applications.

Gemini surfactants also play a pivotal role in the development of smart materials and emerging technologies. This comprehensive review of their research progress aims to deepen our understanding of both their current capabilities and the technological challenges that lie ahead in harnessing their full potential.

Dr. Iwona Kowalczyk
Prof. Dr. Bogumil E. Brycki
Guest Editors

Manuscript Submission Information

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Keywords

  • gemini surfactants
  • biological activity
  • physicochemical analysis
  • smart material

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Published Papers (1 paper)

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Research

24 pages, 2553 KB  
Article
Preliminary Evaluation of Gemini-Surfactant-Based Formulations for Antifungal Seed Treatment in Wheat
by Tomasz Szczygieł, Anna Koziróg, Anna Otlewska and Bogumił Brycki
Molecules 2026, 31(10), 1568; https://doi.org/10.3390/molecules31101568 - 8 May 2026
Viewed by 173
Abstract
This study analyzed the degree of fungal contamination of cereal grains and assessed the potential of gemini surfactants as antifungal agents used in seed dressing. Identification analysis based on the ITS region showed that representatives of the genera Penicillium and Fusarium were most [...] Read more.
This study analyzed the degree of fungal contamination of cereal grains and assessed the potential of gemini surfactants as antifungal agents used in seed dressing. Identification analysis based on the ITS region showed that representatives of the genera Penicillium and Fusarium were most frequently identified among the isolated microorganisms. The sensitivity testing of the gemini surfactants—12-6-12 hexamethylene-1,6-bis(N-dodecyl-N,N-dimethylammonium bromide) and 12-O-12 3-oxa-1,5-pentane-bis(N-dodecyl-N,N-dimethylammonium bromide), as well as formulations derived from them—showed that the growth of mold monocultures was inhibited at concentrations <0.0005–0.0016%. A consortium containing a mixture of five different strains inhibited the growth at concentrations of 0.031–0.125%. In studies of treated grains, both on synthetic media and in pot tests, the following parameters were considered: the type of gemini surfactant in the fungicide, the coating agent concentration, and various filamentous fungi. It was found that wheat grains showed comparatively lower infection levels under the tested conditions for the 12-6-12/N/IT7/S formulation, containing the main active ingredient, hexamethylene-1,6-bis(N,N-dimethyl-N-dodecylammonium) dibromide, and a single concentration of the coating agent. Fusarium sp. monocultures colonized treated grain more quickly than a consortium of five strains. The results indicate that seed coatings based on gemini surfactants may represent a potentially useful approach under controlled conditions; however, further studies including toxicity assessment, environmental impact evaluation, and field validation are required. Full article
(This article belongs to the Special Issue Research Progress of Gemini Surfactants)
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