The Chemical Immobilization and Inactivation of SARS-CoV-2
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1072
Special Issue Editor
Interests: organic synthesis; molecular interactions; surface chemistry; microbiocide chemistry; smart materials; corrosion inhibition; environmental chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The outbreak and spread of SARS-CoV-2 is a serious global threat, unpredictable in its health, economic, and political effects. Tragic consequences of coronavirus infection will be mitigated in the future by vaccines and drugs. It will certainly take a long time. Faster extinction of the pandemic is possible by limiting the proliferation of the virus. Preventing the virus from contacting the host can be achieved by maintaining social distance, disinfection, and the use of materials which immobilize and inactivate viruses.
The surface of SARS-CoV-2 is covered by glycosylated S proteins, which are crucial to the viral life cycle. Therefore, these proteins are potential targets for active substances that can effectively immobilize and inactivate the virus. The formation of covalent or ionic bonds, sequestration, and intermolecular interactions play a fundamental role in the immobilization and inactivation of viruses. The introduction of bioactive substances to natural or synthetic polymers (PP, PLA, PANI, NNMO cellulose, chitosan) by electrospinning, melt-blowing, or other techniques will make it possible to obtain construction materials for protective clothing, masks, curtains, packaging materials, and protective layers forming a barrier to the virus.
The present Special Issue aims to provide an update on the synthesis of stable antiviral agents and their implementation in polymers to get bioactive materials which will limit the proliferation of SARS-CoV-2.
Prof. Dr. Bogumil E. Brycki
Guest Editor
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Keywords
- antiviral agents
- biocidal nanoparticles
- mechanism of immobilization
- antiviral activity
- bioactive polymers
- molecular docking
- applications
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