Novel Metabolism-Related Biomarkers in Cancer

Dear Colleagues,

Cancer is a major global threat to public health, and validated, specific and sensitive cancer biomarkers are increasingly being used to accurately diagnose and manage cancer patients. However, patient treatment remains largely unsuccessful in the long term due to evolving metabolic alterations and intricate signaling within the challenging cancer microenvironment. Metabolic networks sustain fundamental cellular functions, from energy production to biosynthesis, to determine cellular fates. Distinct metabolic signatures are displayed by different cancer types, and increasing understanding of the hallmarks of metabolic reprogramming and plasticity in cancer cells is generating novel metabolism-related biomarkers that show promise in further advancing personalized medicine and improving patients’ outcomes. This Special Issue will highlight recent developments in cancer metabolism-related biomarkers’ discovery and validation, encompassing not only the historical Warburg fundamentals of the glycolytic phenotype, but also other metabolic patterns, such as amino acid, lipid and trace element metabolism, that will certainly contribute to deciphering cancer complexity and aid in directing future therapeutic interventions.

Dr. Maria de Fátima Monginho Baltazar
Dr. Julieta Alexandra Pereira Afonso
Guest Editors

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