Synthesis of Novel Antimicrobial Gels

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 1607

Special Issue Editors


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Guest Editor
Key Laboratory of Quality Evaluation of Medical Biological Protection and Implantable Devices, National Medical Products Administration, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471000, China
Interests: functional hydrogels; antibacterial polymers; hydrogel dressings; amphoteric polymer hydrogels; flexible sensing
Special Issues, Collections and Topics in MDPI journals
School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, China
Interests: biomedical hydrogels; tissue engineering; conductive scaffold; wound healing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial gels comprise a wide range of materials, in which antibacterial components with various characteristics are integrated or incorporated into a robust 3D network to endow gel materials with antimicrobial properties. Gels with antimicrobial properties are currently the focus of research in the biomedical field and are considered important biomaterials due to their integrated advantages of gels and antibacterial materials. Many advanced antibacterial gels have been developed with unique qualities, including high flexibility, enhanced biocompatibility, high oxygen permeability, ease of loading and releasing drugs, and structural diversity. In recent years, some novel antimicrobial gels with intrinsic, long-lasting antibacterial properties have been successively developed, thus further broadening the application fields of antibacterial gels.

The aim of the present Special Issue is to highlight the recent advances in basic and applied research on gels with antimicrobial ability, which includes (but is not limited to) novel methods for their structure design, synthesis, performance, mechanisms of action, and clinical applications. Original research articles, short communications, and reviews are welcome.

Dr. Kun Lei
Dr. Xin Zhao
Prof. Dr. Jianxun Ding
Guest Editors

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Keywords

  • hydrogels
  • aerogels 
  • cryogels
  • organogels
  • ionic gels
  • eutectogels
  • metal nanoparticles
  • metallic oxide nanoparticles
  • antibiotics
  • biological extracts
  • synthetic antibacterial drugs
  • antibacterial polymers
  • antibacterial peptides
  • amphoteric ions
  • photothermal materials
  • nano-enzymes
  • covalent organic frameworks

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Published Papers (1 paper)

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Research

21 pages, 24027 KB  
Article
Multifunctional Prussian-Blue-Based Nanocomposite Hydrogel for Infected Wound Regeneration
by Pengchao Zhao, Zhishen Zhang, Dianhao Gong, Hongzhen Luo, Huiying Yu, Xin Li, Kun Lei, Chunshan Quan, Yun Xue and Lijun Guan
Gels 2025, 11(11), 895; https://doi.org/10.3390/gels11110895 - 8 Nov 2025
Cited by 3 | Viewed by 1136
Abstract
The wound healing (WH) process is often severely hindered by bacterial infections and prolonged inflammatory responses. To address this problem, we developed a novel injectable nanocomposite DPB-ODQ hydrogel, which comprises polydopamine-modified Prussian blue nanoparticles (PB@PDA, also called DPB) and an oxidized dextran/quaternized chitosan [...] Read more.
The wound healing (WH) process is often severely hindered by bacterial infections and prolonged inflammatory responses. To address this problem, we developed a novel injectable nanocomposite DPB-ODQ hydrogel, which comprises polydopamine-modified Prussian blue nanoparticles (PB@PDA, also called DPB) and an oxidized dextran/quaternized chitosan (QCS)-based Schiff-base network. This hydrogel possesses a highly interconnected porous structure, an excellent swelling rate (730%), rapid gelling speed (45 s), a high mass retention rate over a three-day period (73.20%), and exceptional self-healing properties. Based on the presence of PDA and the Schiff base, it also exhibited good adhesive strength (13.5 kPa). In addition, under near-infrared irradiation at 1.0 W/cm2, temperatures increased by more than 35 °C within 5 min, indicating excellent photothermal (PT) performance. The PT performance of DPB, synergized with the inherent antibacterial properties of QCS, endowed it with a bactericidal rate exceeding 96% against both Staphylococcus aureus and Escherichia coli. In vitro cell experiments have shown that it significantly promoted fibroblast proliferation and migration. In experiments involving mice infected with S. aureus, DPB-ODQ demonstrated an impressive WH rate of 92.82%, greatly promoting collagen deposition. Full article
(This article belongs to the Special Issue Synthesis of Novel Antimicrobial Gels)
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