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Polymeric Systems Loaded with Natural Bioactive Compounds, 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1055

Special Issue Editors


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Guest Editor
“Cristofor Simionescu” Faculty of Chemical Engineering and Environment Protection, “Gheorghe Asachi” Technical University, Iasi, Romania
Interests: polysaccharide modification; bioactive polymers; biomaterials; hydrogels; interpenetrated networks; micro- and nanoparticles (spheres and capsules); hybrid and functionalized nanoparticles for drug targeting; drug delivery; polymer–drug conjugates
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Protection of the Environment "Cristofor Simionescu", "Gheroghe Asachi" Technical University of Iasi, Iași, Romania
Interests: polymer drug delivery systems; micro/nanoparticles; hydrogels; drug release kinetics; polysaccharides

Special Issue Information

Dear Colleagues,

Since ancient times, people have used natural products derived from plants and sometimes animals as medicines against various diseases because they show a great structural diversity that influences biological properties and bioavailability. Natural products such as polyphenols, omega-3 fatty acids, phytosterols, carotenoids, vitamins, alkaloids etc., can modulate metabolic processes and demonstrate positive properties such as antioxidant effects, inhibition of receptor activities, inhibition or induction of enzymes, and the induction and inhibition of gene expression. However, most bioactive natural compounds have low water solubility, stability, and bioavailability. Nanotechnology plays an important role in improving these properties, improving their absorption, protecting them from premature degradation in the body, and prolonging their circulation time. Many nanostructured systems have been developed for the loading, transport, and controlled release of the active compound into the body, or even at the specific target of these natural products. These include hydrogels/nanohydrogels, liposomes, polymeric nanoparticles (nanospheres and nanocapsules), solid lipid nanoparticles, nanoemulsions, polymeric micelles, etc.

This Special Issue aims to present the latest aspects regarding the preparation and characterization of natural biologically active principles loaded in polymer-based films, hydrogels, micro/nanoparticles, micelles, capsules, implants, inserts, liposomes stabilized by polymer coatings, etc.

Prof. Dr. Marcel Popa
Dr. Cǎtǎlina Anişoara Peptu 
Guest Editors

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Keywords

  • polymer–natural drug systems
  • polyphenols
  • polymer-drug conjugates
  • biomaterials
  • drug delivery
  • natural bioactive compounds
  • active targeting
  • omega 3 fatty acids
  • carotenoids
  • vitamins

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Published Papers (1 paper)

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Review

17 pages, 5589 KB  
Review
Construction and Advanced Utilization of Self-Assembled and Scale-Down Chitin Nanofibers for Polymer Composite Design
by Masayasu Totani and Jun-ichi Kadokawa
Molecules 2026, 31(2), 364; https://doi.org/10.3390/molecules31020364 - 20 Jan 2026
Viewed by 622
Abstract
This review provides a comprehensive overview of recent progress in chitin-based nanomaterials and their composite engineering. Particular focus is placed on techniques for constructing self-assembled chitin nanofibers (ChNFs) with tightly bundled fibrillar structures, as well as strategies for fabricating composites in which the [...] Read more.
This review provides a comprehensive overview of recent progress in chitin-based nanomaterials and their composite engineering. Particular focus is placed on techniques for constructing self-assembled chitin nanofibers (ChNFs) with tightly bundled fibrillar structures, as well as strategies for fabricating composites in which the ChNFs serve as reinforcing components, combined with natural polymeric matrices. In addition, high-crystalline scaled-down (SD-)ChNFs were fabricated through partial deacetylation of the ChNFs, followed by electrostatic repulsive disassembly of the abovementioned bundled fibrils in aqueous acetic acid, which were further used to reinforce composites comprising the other polysaccharides. Mixing the SD-ChNFs with low-crystalline chitin substrates further enabled the fabrication of all-chitin composites (AChCs) that exploit crystallinity contrast to achieve enhanced tensile strength. Moreover, the AChC films exhibited high cell-adhesive properties and promoted the formation of three-dimensional cell-networks, highlighting their potential for biomedical applications. Full article
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