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Anti-inflammatory Activities of Natural Products—Third Edition
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Anti-inflammatory Activities of Natural Products—Third Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 2015

Special Issue Editor

Dr. Maria da Graça Costa G. Miguel

E-Mail Website
Guest Editor
Mediterranean Institute for Agriculture, Environment and Development, Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
Interests: bee products; medicinal plants; essential oils; anthocyanins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammation involves several steps to respond to harmful stimuli, such as pathogen agents, tissue lesions, and irritants, in order to destroy or isolate those agents, remove damaged tissues, and restore tissue homeostasis. The first step consists of the recognition of infection and damage, the second step consists of the activation of common signaling pathways, and the third step consists of the transcription and translation of genes, that is, the inducible expression of pro-inflammatory cytokines. These molecules, together with chemokines, originate the recruitment of monocytes and neutrophils to a damaged site, passing selectively through endothelial cells with a protein-rich fluid. Whereas acute inflammation involves an immediate and early response to an injurious agent and is quickly resolved, disturbance persists in chronic inflammation. Chronic inflammation is associated with a variety of cardiovascular, metabolic, and neurodegenerative diseases.

Plants, plant products, marine compounds, mushrooms, and bee products (honey, propolis, bee pollen) are examples of materials that have been the target of many studies in order to find effective anti-inflammatory compounds or extracts. Such studies include not only the isolation and identification of compounds but also the determination of the mechanisms involved in the anti-inflammatory activity.

This Special Issue, titled “Anti-inflammatory Activities of Natural Products—Third Edition”, invites researchers to contribute original research or review articles related to the anti-inflammatory activity, including mechanisms and pharmacological characterization, of extracts, fractions, or purified substances (extraction procedures, isolation, and identification) from mushrooms, bee products, marine sources, or plants. This Special Issue will not accept papers reporting only on the activity of extracts but lacking any chemical characterization of their components.

I look forward to receiving your contributions.

Dr. Maria da Graça Costa G. Miguel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • anti-inflammatory
  • natural products
  • pharmacology
  • plant
  • marine

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Related Special Issue

Published Papers (3 papers)

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Research

30 pages, 2241 KiB  
Article
Evaluation of Anti-Inflammatory, Antidiabetic, Antioxidant, and Anticholinergic Activities, as Well as Chemical Composition and Polyphenolic Compounds in Novel SCOBY-Fermented Juices
by Joanna Grondalska and Joanna Kolniak-Ostek
Molecules 2025, 30(9), 1940; https://doi.org/10.3390/molecules30091940 - 27 Apr 2025
Viewed by 143
Abstract
Fermentation processes, which occur under the influence of multiplying microorganisms, lead to the creation of products with beneficial health properties. Due to the growing interest of consumers in beverages with health-promoting properties, new raw materials and their processing methods are being intensively studied [...] Read more.
Fermentation processes, which occur under the influence of multiplying microorganisms, lead to the creation of products with beneficial health properties. Due to the growing interest of consumers in beverages with health-promoting properties, new raw materials and their processing methods are being intensively studied to obtain products with improved functional values. The purpose of the study is to determine the effect of fermentation using SCOBY (Symbiotic Culture of Bacteria and Yeast) on the chemical composition, polyphenolic profile, and biological activity of apple and pear juices. The fermentation process caused a decrease in the content of polyphenols in apple juice from 1568.8 to 1269.0 mg/L, while in pears, an increase was observed from 492.9 to 576.7 mg/L. Statistically significant changes were observed in the content of individual groups of polyphenolic compounds. The fermentation process also influenced the increase in the value of anti-inflammatory, antioxidant, antidiabetic, and anticholinergic activity. This indicates that fermentation can be an effective process in increasing the biological properties of fruit juices. This fact can be used in the prevention of lifestyle diseases and in the production of functional foods with targeted health-promoting properties. Full article
(This article belongs to the Special Issue Anti-inflammatory Activities of Natural Products—Third Edition)
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11 pages, 1275 KiB  
Communication
Genomics-Driven Discovery of Plantariitin A, a New Lipopeptide in Burkholderia plantarii DSM9509
by Xiuling Wang, Zhuo Zhang, Jun Fu and Ruijuan Li
Molecules 2025, 30(4), 868; https://doi.org/10.3390/molecules30040868 - 14 Feb 2025
Viewed by 535
Abstract
A significant number of silent biosynthetic gene clusters (BGCs) within the Burkholderia genome remain uncharacterized, representing a valuable opportunity for the discovery of new natural products. In this research, the recombineering system ETh1h2e_yi23, which facilitates recombination in Burkholderia and was developed in our [...] Read more.
A significant number of silent biosynthetic gene clusters (BGCs) within the Burkholderia genome remain uncharacterized, representing a valuable opportunity for the discovery of new natural products. In this research, the recombineering system ETh1h2e_yi23, which facilitates recombination in Burkholderia and was developed in our previous study, was used for mining the BGCs of B. plantarii DSM9509. By using this recombineering system, the constitutive promoter was precisely inserted into the genome, resulting in the activation of the silent pla BGC, which led to the production of a new lipopeptide named plantariitin A. A distinctive characteristic of this lipopeptide is the incorporation of a non-proteinogenic amino acid residue, i.e., amino-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinepropanoic acid (ATDPP), which has not been identified in other natural products. A biological activity assay demonstrated that plantariitin A exhibits anti-inflammatory activity. This study further substantiates the notion that the in situ activation of silent BGCs is a crucial strategy for the discovery of new natural products within the genus Burkholderia. With the increasing availability of genomic data and the development of bioinformatics tools, Burkholderia is poised to emerge as a prominent source for the development of new lipopeptides. Full article
(This article belongs to the Special Issue Anti-inflammatory Activities of Natural Products—Third Edition)
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33 pages, 6675 KiB  
Article
Evaluation of the Influence of Tanacetum vulgare Extract on Cognitive Functions and Hippocampal BDNF Expression
by Borislava Lechkova, Michaela Shishmanova-Doseva, Niko Benbassat, Reneta Gevrenova, Pepa Atanassova, Nadya Penkova, Lyudmil Peychev, Petar Hrischev, Zhivko Peychev and Stanislava Ivanova
Molecules 2024, 29(23), 5723; https://doi.org/10.3390/molecules29235723 - 4 Dec 2024
Cited by 2 | Viewed by 938
Abstract
Tanacetum vulgare L. has been traditionally applied as a remedy for headaches, rheumatism, digestion, respiratory and neurological problems, and other medical conditions. However, the literature data on its effects on cognitive function are scarce. The aim of the present work was to evaluate [...] Read more.
Tanacetum vulgare L. has been traditionally applied as a remedy for headaches, rheumatism, digestion, respiratory and neurological problems, and other medical conditions. However, the literature data on its effects on cognitive function are scarce. The aim of the present work was to evaluate the effects of two doses of T. vulgare alcohol extract on cognitive functions, hippocampal brain-derived neurotrophic factor (BDNF) expression, and organ toxicity in rats. Rats were treated with T. vulgare 200 mg/kg (TV 200) and 1000 mg/kg (TV 1000) for 28 days. After one week of pre-treatment, the animals were subjected to a series of tests. We found that in the active avoidance test, only TV 200 improved learning and memory, while in the passive avoidance test, both doses facilitated these processes. In addition, the two doses enhanced spatial memory. In the elevated plus maze test, only the higher dose of TV 1000 resulted in anxiolytic-like behavior. Both doses of the extract significantly increased the hippocampal expression of BDNF. We suggest that increased neurotrophic factor expression could be one of the important mechanisms underlying the cognition-enhancing effects of T. vulgare extract. Full article
(This article belongs to the Special Issue Anti-inflammatory Activities of Natural Products—Third Edition)
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