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Integration of Chemical, Biotechnological, and Process Engineering Tools for Sustainable and Circular Food Manufacturing

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 651

Special Issue Editors


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Guest Editor
Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy
Interests: natural products; food chemistry; phytochemical analysis; bioactive compounds; antioxidant activity; antidiabetic potential; plant extracts; nutraceuticals; functional foods; green extraction technologies
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Agraria, Mediterranea University of Reggio Calabria, Località Feo di Vito, 89124 Reggio Calabria, Italy
Interests: food analysis; quality assessment; edible oils; citrus products; chromatographic techniques; functional compounds; food by-products valorization; Mediterranean foods; chemometrics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The global transition toward sustainable and circular food systems requires innovative approaches that merge food chemistry, biotechnology, and food process engineering. The integration of these disciplines enables the valorisation of food by-products, the development of novel bioprocesses, and the optimization of manufacturing pathways to minimize waste, energy consumption, and environmental impact.

This Special Issue of Molecules aims to collect cutting-edge research and comprehensive reviews that explore molecular, biotechnological, and engineering solutions for sustainable food manufacturing. Contributions are welcome that address fundamental studies, applied technologies, and systemic approaches linking chemical characterization, bioconversion, and process intensification within a circular economy framework.

We particularly encourage interdisciplinary works that bridge laboratory-scale molecular insights with industrial-scale process design.

Topics of Interest

  • Green and sustainable chemistry in food manufacturing and processing;
  • Biotechnological valorization of food waste and by-products;
  • Enzymatic and microbial bioprocesses for ingredient recovery and synthesis;
  • Process intensification and integration strategies for circular food production;
  • Novel extraction and purification techniques of food bioactives based on green solvents and biocompatible media;
  • Metabolic and synthetic biology tools for food-grade molecule production;
  • Smart process monitoring and control in bioprocess and food engineering;
  • Upcycling of agro-industrial residues through combined chemical and biotechnological routes;
  • Molecular characterization of bioactive compounds in sustainable formulations.

We look forward to receiving your submissions.

Dr. Monica Rosa Loizzo
Dr. Vincenzo Sicari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sustainability
  • circular economy
  • food manufacturing
  • green chemistry
  • bioprocess engineering
  • biotechnology
  • process intensification
  • waste valorization
  • enzyme technology

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Published Papers (1 paper)

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Research

36 pages, 18625 KB  
Article
Integrated Zero By-Product Valorization of Orange Peel into Multifunctional Pectocellulosic-ZnO Nanocomposite Films for Sustainable Packaging
by Safa Baraketi, Yosr Barchouchi, Cyrine Amara, Riadh Bez, Yassine M’Rabet, Ana Sanches Silva and Khaoula Khwaldia
Molecules 2026, 31(8), 1297; https://doi.org/10.3390/molecules31081297 - 16 Apr 2026
Viewed by 401
Abstract
Agri-food waste valorization is critical for advancing sustainable packaging solutions. Citrus processing generates large amounts of peel residues that are often discarded, despite being rich in valuable biopolymers. This study presents a fully integrated, zero by-product valorization strategy for the fabrication and characterization [...] Read more.
Agri-food waste valorization is critical for advancing sustainable packaging solutions. Citrus processing generates large amounts of peel residues that are often discarded, despite being rich in valuable biopolymers. This study presents a fully integrated, zero by-product valorization strategy for the fabrication and characterization of pectocellulosic nanocomposite films derived from orange peel (OP) biomass. Orange peel extract (OPE) was prepared and used for the biosynthesis of ZnO nanoparticles (NPs), while cellulose was obtained after the depectinization reinforced the pectin-rich supernatant used as the film-forming matrix (0–15% w/w). The optimized formulation containing 5% cellulose enhanced tensile strength by approximately 103% and reduced water vapor permeability by about 12.5% compared to the control, while maintaining structural homogeneity. Higher cellulose loading (≥10%) induced pore formation and compromised barrier and biological performance. Incorporation of ZnO NPs (1–5% w/w) into the optimized matrix further improved stiffness (YM = 163.9 MPa), improved UV-shielding capacity, antimicrobial activity (inhibition zones up to 16.0 mm), and antioxidant performance (98.2% ABTS inhibition). Biodegradation remained statistically unaffected by ZnO incorporation, with films retaining 29–35% degradation within 33 days. Overall, this work demonstrates the transformation of OP waste into multifunctional biodegradable active packaging materials, reinforcing circular bioeconomy principles. Full article
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